Metabolic syndrome and early carotid atherosclerosis in the elderly

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Abstract

Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (≥1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1% men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3%) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95% confidence interval [CI]: 1.059- 3.466), white blood cell count (HR=1.313; 95% CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95% CI: 1.000-1.002) and total cholesterol (HR=1.009; 95% CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process.

Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalJournal of Atherosclerosis and Thrombosis
Volume21
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Carotid Intima-Media Thickness
Carotid Artery Diseases
Hazards
Confidence Intervals
Regression analysis
Regression Analysis
Ultrasonography
Vitamin B 12
Linear regression
Blood
Leukocyte Count
Cholesterol
Cells
Population
Linear Models

Keywords

  • Atherosclerotic plaque
  • Carotid arteries
  • Carotid intima-media thickness

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

@article{315af347fc354fe8bd56a3d73e37051b,
title = "Metabolic syndrome and early carotid atherosclerosis in the elderly",
abstract = "Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (≥1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1{\%} men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3{\%}) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95{\%} confidence interval [CI]: 1.059- 3.466), white blood cell count (HR=1.313; 95{\%} CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95{\%} CI: 1.000-1.002) and total cholesterol (HR=1.009; 95{\%} CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process.",
keywords = "Atherosclerotic plaque, Carotid arteries, Carotid intima-media thickness",
author = "Jin-Man Jung and Do-Young Kwon and Changsu Han and Park, {Moon Ho}",
year = "2014",
month = "1",
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doi = "10.5551/jat.18655",
language = "English",
volume = "21",
pages = "435--444",
journal = "Journal of Atherosclerosis and Thrombosis",
issn = "1340-3478",
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T1 - Metabolic syndrome and early carotid atherosclerosis in the elderly

AU - Jung, Jin-Man

AU - Kwon, Do-Young

AU - Han, Changsu

AU - Park, Moon Ho

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (≥1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1% men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3%) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95% confidence interval [CI]: 1.059- 3.466), white blood cell count (HR=1.313; 95% CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95% CI: 1.000-1.002) and total cholesterol (HR=1.009; 95% CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process.

AB - Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (≥1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1% men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3%) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95% confidence interval [CI]: 1.059- 3.466), white blood cell count (HR=1.313; 95% CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95% CI: 1.000-1.002) and total cholesterol (HR=1.009; 95% CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process.

KW - Atherosclerotic plaque

KW - Carotid arteries

KW - Carotid intima-media thickness

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DO - 10.5551/jat.18655

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EP - 444

JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

SN - 1340-3478

IS - 5

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