Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer

Inseon Ryoo, Hyuknam Kwon, Soo Chin Kim, Seung Chai Jung, Jeong A. Yeom, Hwa Seon Shin, Hye Rim Cho, Tae Jin Yun, Seung Hong Choi, Chul Ho Sohn, Sunghyouk Park, Ji Hoon Kim

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Abstract

Thyroid nodules are a very common problem. Since malignant thyroid nodules should be treated surgically, preoperative diagnosis of thyroid cancer is very crucial. Cytopathologic analysis of percutaneous fine-needle aspiration (FNA) specimens is the current gold standard for diagnosing thyroid nodules. However, this method has led to high rates of inconclusive results. Metabolomics has emerged as a useful tool in medical fields and shown great potential in diagnosing various cancers. Here, we evaluated the potential of nuclear magnetic resonance (NMR) analysis of percutaneous FNA specimens for preoperative diagnosis of thyroid cancer. We analyzed metabolome of FNA samples of papillary thyroid carcinoma (n = 35) and benign follicular nodule (n = 69) using a proton NMR spectrometer. The metabolomic profiles showed a considerable discrimination between benign and malignant nodules. Receiver operating characteristic (ROC) curve analysis indicated that seven metabolites could serve as discriminators (area under ROC curve value, 0.64-0.85). These findings demonstrated that NMR analysis of percutaneous FNA specimens of thyroid nodules can be potentially useful in the accurate and rapid preoperative diagnosis of thyroid cancer.

Original languageEnglish
Article number30075
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Jul 21

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Thyroid Nodule
Metabolomics
Fine Needle Biopsy
Thyroid Neoplasms
Magnetic Resonance Spectroscopy
ROC Curve
Metabolome
Protons
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules : Potential application for the preoperative diagnosis of thyroid cancer. / Ryoo, Inseon; Kwon, Hyuknam; Kim, Soo Chin; Jung, Seung Chai; Yeom, Jeong A.; Shin, Hwa Seon; Cho, Hye Rim; Yun, Tae Jin; Choi, Seung Hong; Sohn, Chul Ho; Park, Sunghyouk; Kim, Ji Hoon.

In: Scientific Reports, Vol. 6, 30075, 21.07.2016.

Research output: Contribution to journalArticle

Ryoo, Inseon ; Kwon, Hyuknam ; Kim, Soo Chin ; Jung, Seung Chai ; Yeom, Jeong A. ; Shin, Hwa Seon ; Cho, Hye Rim ; Yun, Tae Jin ; Choi, Seung Hong ; Sohn, Chul Ho ; Park, Sunghyouk ; Kim, Ji Hoon. / Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules : Potential application for the preoperative diagnosis of thyroid cancer. In: Scientific Reports. 2016 ; Vol. 6.
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