Metabolomic differentiation of deer antlers of various origins by 1H NMR spectrometry and principal components analysis

Hyung Kyoon Choi, Kyoung Hee Kim, Kyoung Heon Kim, Young Suk Kim, Min Won Lee, Wan Kyun Whang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The metabolomic analysis of various types of deer antler was performed by 1H NMR spectrometry and principal components analysis (PCA). The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2, and PC3), which cumulatively accounted for 93.5% of the variation in all variables. In particular, the score plots by the combination of PC1 and PC3 allowed an excellent separation of the antler samples. In addition, the major peaks in 1H NMR spectra contributing to the discrimination were assigned to lactate, alanine, acetic acid, choline, glycine, valine, tyrosine, and phenylalanine. This metabolomic-analysis-based method allows various types of deer antler to be efficiently differentiated without any pre-purification steps.

Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume41
Issue number3
DOIs
Publication statusPublished - 2006 Jun 7

Fingerprint

Antlers
Deer
Metabolomics
Principal Component Analysis
Principal component analysis
Spectrometry
Spectrum Analysis
Nuclear magnetic resonance
Valine
Choline
Phenylalanine
Acetic Acid
Alanine
Glycine
Purification
Tyrosine
Lactic Acid
Proton Magnetic Resonance Spectroscopy

Keywords

  • H NMR
  • Deer antler
  • Metabolomic analysis
  • Principal component analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Metabolomic differentiation of deer antlers of various origins by 1H NMR spectrometry and principal components analysis. / Choi, Hyung Kyoon; Kim, Kyoung Hee; Kim, Kyoung Heon; Kim, Young Suk; Lee, Min Won; Whang, Wan Kyun.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 41, No. 3, 07.06.2006, p. 1047-1050.

Research output: Contribution to journalArticle

Choi, Hyung Kyoon ; Kim, Kyoung Hee ; Kim, Kyoung Heon ; Kim, Young Suk ; Lee, Min Won ; Whang, Wan Kyun. / Metabolomic differentiation of deer antlers of various origins by 1H NMR spectrometry and principal components analysis. In: Journal of Pharmaceutical and Biomedical Analysis. 2006 ; Vol. 41, No. 3. pp. 1047-1050.
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