Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics

Yong Deok Lee, Hyeon Jeong Shin, Jounghyun Yoo, Gayoung Kim, Min Kyoung Kang, Jae Jun Lee, Joona Bang, Jin Kyoung Yang, Sehoon Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Indocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding to serum proteins, subjected to rapid clearance and decreased theranostic efficacy in vivo. This study reports stable and biocompatible nanoparticles of ICG (ICG-Fe NPs) where ICG is electrostatically complexed with an endogenously abundant metal ion (Fe3+) and subsequently nanoformulated with a clinically approved polymer surfactant, Pluronic F127. Under near-infrared laser irradiation, ICG-Fe NPs were found to be more effective for photothermal temperature elevation than free ICG molecules owing to the improved photostability. In addition, ICG-Fe NPs showed the markedly enhanced tumor targeting and visualization with photoacoustic/fluorescent signaling upon intravenous injection, attributed to the stable metal complexation that prevents ICG-Fe NPs from releasing free ICG before tumor targeting. Under dual-modal imaging guidance, ICG-Fe NPs could successfully potentiate photothermal therapy of cancer by applying near-infrared laser irradiation, holding potential as a promising nanomedicine composed of all biocompatible ingredients for clinically relevant phototheranostics.

Original languageEnglish
Article number36
JournalNano Convergence
Volume8
Issue number1
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • Dual-modal imaging
  • Indocyanine green
  • Metal complex
  • Photothermal therapy
  • Theranostics

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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