Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride

Subeen Yu, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

Original languageEnglish
Pages (from-to)1613-1616
Number of pages4
JournalAsian Journal of Organic Chemistry
Issue number9
Publication statusPublished - 2019 Sep 1


  • amides
  • amines
  • metal-free chemistry
  • transamidation
  • trimethylsilyl chloride

ASJC Scopus subject areas

  • Organic Chemistry


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