Metastasis-associated protein 1 transgenic mice: A new model of spontaneous B-cell lymphomas

Rozita Bagheri-Yarmand, Seetharaman Balasenthil, Anupama E. Gururaj, Amjad H. Talukder, Yui Hsi Wang, Ju-Han Lee, Young Sik Kim, Xinaglan Zhang, Daniel M. Jones, L. Jeffrey Medeiros, L. Clifton Stephens, Yong Jun Liu, Norman Lee, Insun Kim, Rakesh Kumar

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16 Citations (Scopus)

Abstract

Metastasis-associated protein 1 (MTA1), a component of the nuclear remodeling complex and the founding homologue of the MTA family, has been implicated in metastasis, but definitive causative evidence in an animal model system is currently lacking. Here, we show that MTA1 overexpression in transgenic mice is accompanied by a high incidence of spontaneous B cell lymphomas including diffuse large B cell lymphomas (DLBCL). Lymphocytes and lymphoma cells from MTA1-TG mice are hyperproliferative. Lymphomas were transplantable and of clonal origin and were characterized by down-regulation of p27Kip1 as well as up-regulation of Bcl2 and cyclin D1. The significance of these murine studies was established by evidence showing a widespread up-regulation of MTA1 in DLBCL from humans. These findings reveal a previously unrecognized role for the MTA1 pathway in the development of spontaneous B cell lymphomas, and offer a potential therapeutic target in B cell lymphomas. These observations suggest that MTA1-TG mice represent a new model of spontaneous DLBCL associated with high tumor incidence and could be used for therapeutic intervention studies.

Original languageEnglish
Pages (from-to)7062-7067
Number of pages6
JournalCancer Research
Volume67
Issue number15
DOIs
Publication statusPublished - 2007 Aug 1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Bagheri-Yarmand, R., Balasenthil, S., Gururaj, A. E., Talukder, A. H., Wang, Y. H., Lee, J-H., Kim, Y. S., Zhang, X., Jones, D. M., Medeiros, L. J., Stephens, L. C., Liu, Y. J., Lee, N., Kim, I., & Kumar, R. (2007). Metastasis-associated protein 1 transgenic mice: A new model of spontaneous B-cell lymphomas. Cancer Research, 67(15), 7062-7067. https://doi.org/10.1158/0008-5472.CAN-07-0748