Metastatic lymph node targeted chemosensitivity test for gastric cancer

You Jin Jang, Jong Han Kim, Sung Soo Park, Seong Heum Park, Seung Joo Kim, Chong Suk Kim, Young Jae Mok

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    1 Citation (Scopus)

    Abstract

    Background: The objective of this study was to compare the chemosensitivity of primary tumor and metastasized lymph node from patient with gastric adenocarcinoma. Materials and Methods: We studied 26 gastric cancer patients with lymph node metastasis who underwent gastric resection at the Korea University Guro Hospital from Feb 2007 to July 2008. The chemosensitivity of primary tumor and metastatic lymph node were studied using an adenosine triphosphate-based chemotherapy response assay (ATP-CRA). Results: The concordance rate of the ATP-CRA test was 30.8% (8/26). The concordance rate between primary tumor and metastatic N2 group lymph node was only 9.1% (1/11). The metastatic tumor inhibition rates with 5-fluorouracil, cisplatin, doxorubicin, and oxaliplatin were higher than the inhibition rates for primary tumor. Tumor inhibition rates was significantly different between primary tumor and metastatic tumor after doxorubicin treatment (27.734 ± 20.95 versus 38.403 ± 26.87, P = 0.021). We detected simple correlations of tumor inhibition rates between primary and metastatic tumors with cisplatin (r = 0.661, P < 0.001) and doxorubicin (r = 0.475, P = 0.031). Conclusions: We observed differences between first choice chemotherapeutic agents based on ATPCRA tests of primary tumor and metastatic tumor in lymph node. Therefore, chemotherapeutic agents should be carefully selected for adjuvant chemotherapy using a chemosensitivity test.

    Original languageEnglish
    Pages (from-to)657-662
    Number of pages6
    JournalJournal of Surgical Research
    Volume171
    Issue number2
    DOIs
    Publication statusPublished - 2011 Dec

    Keywords

    • chemosensitivity test
    • gastric cancer
    • tumor heterogeneity

    ASJC Scopus subject areas

    • Surgery

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