Metastatic lymph node targeted chemosensitivity test for gastric cancer

Research output: Contribution to journalArticle

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Abstract

Background: The objective of this study was to compare the chemosensitivity of primary tumor and metastasized lymph node from patient with gastric adenocarcinoma. Materials and Methods: We studied 26 gastric cancer patients with lymph node metastasis who underwent gastric resection at the Korea University Guro Hospital from Feb 2007 to July 2008. The chemosensitivity of primary tumor and metastatic lymph node were studied using an adenosine triphosphate-based chemotherapy response assay (ATP-CRA). Results: The concordance rate of the ATP-CRA test was 30.8% (8/26). The concordance rate between primary tumor and metastatic N2 group lymph node was only 9.1% (1/11). The metastatic tumor inhibition rates with 5-fluorouracil, cisplatin, doxorubicin, and oxaliplatin were higher than the inhibition rates for primary tumor. Tumor inhibition rates was significantly different between primary tumor and metastatic tumor after doxorubicin treatment (27.734 ± 20.95 versus 38.403 ± 26.87, P = 0.021). We detected simple correlations of tumor inhibition rates between primary and metastatic tumors with cisplatin (r = 0.661, P < 0.001) and doxorubicin (r = 0.475, P = 0.031). Conclusions: We observed differences between first choice chemotherapeutic agents based on ATPCRA tests of primary tumor and metastatic tumor in lymph node. Therefore, chemotherapeutic agents should be carefully selected for adjuvant chemotherapy using a chemosensitivity test.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalJournal of Surgical Research
Volume171
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Stomach Neoplasms
Lymph Nodes
Neoplasms
Doxorubicin
oxaliplatin
Cisplatin
Stomach
Adenosine Triphosphate
Drug Therapy
Adjuvant Chemotherapy
Korea
Fluorouracil
Adenocarcinoma
Neoplasm Metastasis

Keywords

  • chemosensitivity test
  • gastric cancer
  • tumor heterogeneity

ASJC Scopus subject areas

  • Surgery

Cite this

Metastatic lymph node targeted chemosensitivity test for gastric cancer. / Jang, You-Jin; Kim, Jong Han; Park, Sungsoo; Park, Seong-Heum; Kim, Seung Joo; Kim, Chong Suk; Mok, Young Jae.

In: Journal of Surgical Research, Vol. 171, No. 2, 01.12.2011, p. 657-662.

Research output: Contribution to journalArticle

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abstract = "Background: The objective of this study was to compare the chemosensitivity of primary tumor and metastasized lymph node from patient with gastric adenocarcinoma. Materials and Methods: We studied 26 gastric cancer patients with lymph node metastasis who underwent gastric resection at the Korea University Guro Hospital from Feb 2007 to July 2008. The chemosensitivity of primary tumor and metastatic lymph node were studied using an adenosine triphosphate-based chemotherapy response assay (ATP-CRA). Results: The concordance rate of the ATP-CRA test was 30.8{\%} (8/26). The concordance rate between primary tumor and metastatic N2 group lymph node was only 9.1{\%} (1/11). The metastatic tumor inhibition rates with 5-fluorouracil, cisplatin, doxorubicin, and oxaliplatin were higher than the inhibition rates for primary tumor. Tumor inhibition rates was significantly different between primary tumor and metastatic tumor after doxorubicin treatment (27.734 ± 20.95 versus 38.403 ± 26.87, P = 0.021). We detected simple correlations of tumor inhibition rates between primary and metastatic tumors with cisplatin (r = 0.661, P < 0.001) and doxorubicin (r = 0.475, P = 0.031). Conclusions: We observed differences between first choice chemotherapeutic agents based on ATPCRA tests of primary tumor and metastatic tumor in lymph node. Therefore, chemotherapeutic agents should be carefully selected for adjuvant chemotherapy using a chemosensitivity test.",
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AU - Kim, Chong Suk

AU - Mok, Young Jae

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AB - Background: The objective of this study was to compare the chemosensitivity of primary tumor and metastasized lymph node from patient with gastric adenocarcinoma. Materials and Methods: We studied 26 gastric cancer patients with lymph node metastasis who underwent gastric resection at the Korea University Guro Hospital from Feb 2007 to July 2008. The chemosensitivity of primary tumor and metastatic lymph node were studied using an adenosine triphosphate-based chemotherapy response assay (ATP-CRA). Results: The concordance rate of the ATP-CRA test was 30.8% (8/26). The concordance rate between primary tumor and metastatic N2 group lymph node was only 9.1% (1/11). The metastatic tumor inhibition rates with 5-fluorouracil, cisplatin, doxorubicin, and oxaliplatin were higher than the inhibition rates for primary tumor. Tumor inhibition rates was significantly different between primary tumor and metastatic tumor after doxorubicin treatment (27.734 ± 20.95 versus 38.403 ± 26.87, P = 0.021). We detected simple correlations of tumor inhibition rates between primary and metastatic tumors with cisplatin (r = 0.661, P < 0.001) and doxorubicin (r = 0.475, P = 0.031). Conclusions: We observed differences between first choice chemotherapeutic agents based on ATPCRA tests of primary tumor and metastatic tumor in lymph node. Therefore, chemotherapeutic agents should be carefully selected for adjuvant chemotherapy using a chemosensitivity test.

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