Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells

Soon Young Jang, Aeree Kim, Jin Kyoung Kim, Chungyel Kim, Youl Hee Cho, Jong Ho Kim, Chul Hwan Kim, Ji Yun Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.

Original languageEnglish
Pages (from-to)4127-4134
Number of pages8
JournalAnticancer research
Volume34
Issue number8
Publication statusPublished - 2014 Aug 1

Keywords

  • Invasion
  • MMP9
  • Metformin
  • Migration
  • Tamoxifen resistance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells'. Together they form a unique fingerprint.

  • Cite this

    Jang, S. Y., Kim, A., Kim, J. K., Kim, C., Cho, Y. H., Kim, J. H., Kim, C. H., & Lee, J. Y. (2014). Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells. Anticancer research, 34(8), 4127-4134.