Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Byung Cheon Lee, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V. Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G. Harshman, Vadim N. Gladyshev

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

Original languageEnglish
Article number3592
JournalNature communications
Volume5
DOIs
Publication statusPublished - 2014 Apr 7
Externally publishedYes

Fingerprint

Drosophila
methionine
Drosophila melanogaster
Methionine
amino acids
constrictions
Amino Acids
Reproduction
Aging of materials
rodents
fruits
yeast
Fruits
Diptera
Yeast
Rodentia
Fruit
Yeasts

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status. / Lee, Byung Cheon; Kaya, Alaattin; Ma, Siming; Kim, Gwansu; Gerashchenko, Maxim V.; Yim, Sun Hee; Hu, Zhen; Harshman, Lawrence G.; Gladyshev, Vadim N.

In: Nature communications, Vol. 5, 3592, 07.04.2014.

Research output: Contribution to journalArticle

Lee, BC, Kaya, A, Ma, S, Kim, G, Gerashchenko, MV, Yim, SH, Hu, Z, Harshman, LG & Gladyshev, VN 2014, 'Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status', Nature communications, vol. 5, 3592. https://doi.org/10.1038/ncomms4592
Lee, Byung Cheon ; Kaya, Alaattin ; Ma, Siming ; Kim, Gwansu ; Gerashchenko, Maxim V. ; Yim, Sun Hee ; Hu, Zhen ; Harshman, Lawrence G. ; Gladyshev, Vadim N. / Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status. In: Nature communications. 2014 ; Vol. 5.
@article{7a44ace24da343828c2c79d0d12019a1,
title = "Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status",
abstract = "Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.",
author = "Lee, {Byung Cheon} and Alaattin Kaya and Siming Ma and Gwansu Kim and Gerashchenko, {Maxim V.} and Yim, {Sun Hee} and Zhen Hu and Harshman, {Lawrence G.} and Gladyshev, {Vadim N.}",
year = "2014",
month = "4",
day = "7",
doi = "10.1038/ncomms4592",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

AU - Lee, Byung Cheon

AU - Kaya, Alaattin

AU - Ma, Siming

AU - Kim, Gwansu

AU - Gerashchenko, Maxim V.

AU - Yim, Sun Hee

AU - Hu, Zhen

AU - Harshman, Lawrence G.

AU - Gladyshev, Vadim N.

PY - 2014/4/7

Y1 - 2014/4/7

N2 - Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

AB - Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

UR - http://www.scopus.com/inward/record.url?scp=84901816229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901816229&partnerID=8YFLogxK

U2 - 10.1038/ncomms4592

DO - 10.1038/ncomms4592

M3 - Article

C2 - 24710037

AN - SCOPUS:84901816229

VL - 5

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 3592

ER -