Methylation of AKAP12α promoter in lung cancer

Uk Hyun Jo, Young Mi Whang, Jae Sook Sung, Yeul Hong Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

AKAP12α plays an important role in tumour growth suppression by inducing apoptosis. This study investigated whether the promoter methylation of AKAP12α is associated with lung cancer. AKAP12α was down-regulated in lung cancer cells and the reduced protein expression was restored by DNA methyl-transferase inhibitor. AKAP12α promoter was more frequently methylated in tumours than in normal tissues. Furthermore, AKAP12α methylation was found more frequently in the cells of non-relapse patients after surgery than in those of early relapse patients. In conclusion, this study demonstrated that AKAP12α expression is regulated by DNA methylation and that AKAP12α promoter methylation is associated with lung cancer prognosis.

Original languageEnglish
Pages (from-to)4595-4600
Number of pages6
JournalAnticancer research
Volume30
Issue number11
Publication statusPublished - 2010 Nov 1

    Fingerprint

Keywords

  • AKAP12α
  • Lung neoplasms
  • NSCLC
  • Promoter methylation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jo, U. H., Whang, Y. M., Sung, J. S., & Kim, Y. H. (2010). Methylation of AKAP12α promoter in lung cancer. Anticancer research, 30(11), 4595-4600.