Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference

Su Yeon Choi, Kihoon Han, Tyler Cutforth, Woosuk Chung, Haram Park, Dongsoo Lee, Ryunhee Kim, Myeong Heui Kim, Yeeun Choi, Kang Shen, Eunjoon Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2-/- mice) display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests. These mice also show normal levels of anxiety-like behaviors, social interaction, and repetitive behaviors. At the synapse level, Neph2-/- dentate gyrus granule cells exhibit unaltered dendritic spine density and spontaneous excitatory synaptic transmission. These results suggest that Neph2 is important for normal locomotor activity and object recognition memory.

Original languageEnglish
Article number283
JournalFrontiers in Cellular Neuroscience
Volume9
Issue numberJULY
DOIs
Publication statusPublished - 2015 Jul 28

Fingerprint

Synapses
Jacobsen Distal 11q Deletion Syndrome
Maze Learning
Dendritic Spines
Dentate Gyrus
Locomotion
Interpersonal Relations
Synaptic Transmission
Intellectual Disability
Fear
Immunoglobulins
Anxiety
Water
Recognition (Psychology)
Spatial Learning
Autism Spectrum Disorder
Conditioning (Psychology)
Psychological Extinction
Spatial Memory

Keywords

  • Autism spectrum disorder
  • Cognition
  • Hyperactivity
  • Intellectual disability
  • Memory
  • Synaptic adhesion
  • Synaptic transmission

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference. / Choi, Su Yeon; Han, Kihoon; Cutforth, Tyler; Chung, Woosuk; Park, Haram; Lee, Dongsoo; Kim, Ryunhee; Kim, Myeong Heui; Choi, Yeeun; Shen, Kang; Kim, Eunjoon.

In: Frontiers in Cellular Neuroscience, Vol. 9, No. JULY, 283, 28.07.2015.

Research output: Contribution to journalArticle

Choi, Su Yeon ; Han, Kihoon ; Cutforth, Tyler ; Chung, Woosuk ; Park, Haram ; Lee, Dongsoo ; Kim, Ryunhee ; Kim, Myeong Heui ; Choi, Yeeun ; Shen, Kang ; Kim, Eunjoon. / Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference. In: Frontiers in Cellular Neuroscience. 2015 ; Vol. 9, No. JULY.
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AU - Lee, Dongsoo

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