Abstract
Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2-/- mice) display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests. These mice also show normal levels of anxiety-like behaviors, social interaction, and repetitive behaviors. At the synapse level, Neph2-/- dentate gyrus granule cells exhibit unaltered dendritic spine density and spontaneous excitatory synaptic transmission. These results suggest that Neph2 is important for normal locomotor activity and object recognition memory.
| Original language | English |
|---|---|
| Article number | 283 |
| Journal | Frontiers in Cellular Neuroscience |
| Volume | 9 |
| Issue number | JULY |
| DOIs | |
| Publication status | Published - 2015 Jul 28 |
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Keywords
- Autism spectrum disorder
- Cognition
- Hyperactivity
- Intellectual disability
- Memory
- Synaptic adhesion
- Synaptic transmission
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
Cite this
Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference. / Choi, Su Yeon; Han, Kihoon; Cutforth, Tyler; Chung, Woosuk; Park, Haram; Lee, Dongsoo; Kim, Ryunhee; Kim, Myeong Heui; Choi, Yeeun; Shen, Kang; Kim, Eunjoon.
In: Frontiers in Cellular Neuroscience, Vol. 9, No. JULY, 283, 28.07.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference
AU - Choi, Su Yeon
AU - Han, Kihoon
AU - Cutforth, Tyler
AU - Chung, Woosuk
AU - Park, Haram
AU - Lee, Dongsoo
AU - Kim, Ryunhee
AU - Kim, Myeong Heui
AU - Choi, Yeeun
AU - Shen, Kang
AU - Kim, Eunjoon
PY - 2015/7/28
Y1 - 2015/7/28
N2 - Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2-/- mice) display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests. These mice also show normal levels of anxiety-like behaviors, social interaction, and repetitive behaviors. At the synapse level, Neph2-/- dentate gyrus granule cells exhibit unaltered dendritic spine density and spontaneous excitatory synaptic transmission. These results suggest that Neph2 is important for normal locomotor activity and object recognition memory.
AB - Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2-/- mice) display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests. These mice also show normal levels of anxiety-like behaviors, social interaction, and repetitive behaviors. At the synapse level, Neph2-/- dentate gyrus granule cells exhibit unaltered dendritic spine density and spontaneous excitatory synaptic transmission. These results suggest that Neph2 is important for normal locomotor activity and object recognition memory.
KW - Autism spectrum disorder
KW - Cognition
KW - Hyperactivity
KW - Intellectual disability
KW - Memory
KW - Synaptic adhesion
KW - Synaptic transmission
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UR - http://www.scopus.com/inward/citedby.url?scp=84940184047&partnerID=8YFLogxK
U2 - 10.3389/fncel.2015.00283
DO - 10.3389/fncel.2015.00283
M3 - Article
AN - SCOPUS:84940184047
VL - 9
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
SN - 1662-5102
IS - JULY
M1 - 283
ER -