Micellar phytosterols effectively reduce cholesterol absorption at low doses

Min-Jeong Shin, Ho Lee Jong, Yangsoo Jang, C. L K Yang, Eunju Park, Mee Kim Kyung, Chul Chung Bong, Namsik Chung

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3% at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0% at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume49
Issue number5
DOIs
Publication statusPublished - 2005 Sep 1
Externally publishedYes

Fingerprint

Phytosterols
Cholesterol
Meals
Placebos
Isotopes
Gas Chromatography-Mass Spectrometry
Cross-Over Studies
Linear Models

Keywords

  • Cholesterol absorption
  • Hexadeuterated cholesterol
  • Phytosterols

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism

Cite this

Shin, M-J., Jong, H. L., Jang, Y., Yang, C. L. K., Park, E., Kyung, M. K., ... Chung, N. (2005). Micellar phytosterols effectively reduce cholesterol absorption at low doses. Annals of Nutrition and Metabolism, 49(5), 346-351. https://doi.org/10.1159/000087880

Micellar phytosterols effectively reduce cholesterol absorption at low doses. / Shin, Min-Jeong; Jong, Ho Lee; Jang, Yangsoo; Yang, C. L K; Park, Eunju; Kyung, Mee Kim; Bong, Chul Chung; Chung, Namsik.

In: Annals of Nutrition and Metabolism, Vol. 49, No. 5, 01.09.2005, p. 346-351.

Research output: Contribution to journalArticle

Shin, M-J, Jong, HL, Jang, Y, Yang, CLK, Park, E, Kyung, MK, Bong, CC & Chung, N 2005, 'Micellar phytosterols effectively reduce cholesterol absorption at low doses', Annals of Nutrition and Metabolism, vol. 49, no. 5, pp. 346-351. https://doi.org/10.1159/000087880
Shin, Min-Jeong ; Jong, Ho Lee ; Jang, Yangsoo ; Yang, C. L K ; Park, Eunju ; Kyung, Mee Kim ; Bong, Chul Chung ; Chung, Namsik. / Micellar phytosterols effectively reduce cholesterol absorption at low doses. In: Annals of Nutrition and Metabolism. 2005 ; Vol. 49, No. 5. pp. 346-351.
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