Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution

Su Hoon Lim, Eui Joon Cha, June Huh, Cheol Hee Ahn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Multi-arm poly(THF)-b-polyglycerol linear-hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi-arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4-arm poly(THF)-b-polygly- cerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration-independent stability in the blood stream.

Original languageEnglish
Pages (from-to)1734-1738
Number of pages5
JournalMacromolecular Chemistry and Physics
Volume210
Issue number20
DOIs
Publication statusPublished - 2009 Oct 22
Externally publishedYes

Fingerprint

Micelles
Critical micelle concentration
micelles
copolymers
Copolymers
aqueous solutions
glycidol
Ring opening polymerization
Drug delivery
Silver
Block copolymers
polymerization
Polymers
Blood
Polymerization
Catalysts
initiators
tetrahydrofuran
Geometry
sulfonates

Keywords

  • Block copolymers
  • Hyperbranched
  • Micelles
  • Ring-opening polymerization

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution. / Lim, Su Hoon; Cha, Eui Joon; Huh, June; Ahn, Cheol Hee.

In: Macromolecular Chemistry and Physics, Vol. 210, No. 20, 22.10.2009, p. 1734-1738.

Research output: Contribution to journalArticle

Lim, Su Hoon ; Cha, Eui Joon ; Huh, June ; Ahn, Cheol Hee. / Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution. In: Macromolecular Chemistry and Physics. 2009 ; Vol. 210, No. 20. pp. 1734-1738.
@article{5c2e3ee803734ad7bda9ab5cc9cb7ed8,
title = "Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution",
abstract = "Multi-arm poly(THF)-b-polyglycerol linear-hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi-arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4-arm poly(THF)-b-polygly- cerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration-independent stability in the blood stream.",
keywords = "Block copolymers, Hyperbranched, Micelles, Ring-opening polymerization",
author = "Lim, {Su Hoon} and Cha, {Eui Joon} and June Huh and Ahn, {Cheol Hee}",
year = "2009",
month = "10",
day = "22",
doi = "10.1002/macp.200900217",
language = "English",
volume = "210",
pages = "1734--1738",
journal = "Macromolecular Chemistry and Physics",
issn = "1022-1352",
publisher = "Wiley-VCH Verlag",
number = "20",

}

TY - JOUR

T1 - Micelle behavior of copolymers composed of linear and hyperbranched blocks in aqueous solution

AU - Lim, Su Hoon

AU - Cha, Eui Joon

AU - Huh, June

AU - Ahn, Cheol Hee

PY - 2009/10/22

Y1 - 2009/10/22

N2 - Multi-arm poly(THF)-b-polyglycerol linear-hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi-arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4-arm poly(THF)-b-polygly- cerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration-independent stability in the blood stream.

AB - Multi-arm poly(THF)-b-polyglycerol linear-hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi-arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4-arm poly(THF)-b-polygly- cerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration-independent stability in the blood stream.

KW - Block copolymers

KW - Hyperbranched

KW - Micelles

KW - Ring-opening polymerization

UR - http://www.scopus.com/inward/record.url?scp=70350509099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350509099&partnerID=8YFLogxK

U2 - 10.1002/macp.200900217

DO - 10.1002/macp.200900217

M3 - Article

AN - SCOPUS:70350509099

VL - 210

SP - 1734

EP - 1738

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

SN - 1022-1352

IS - 20

ER -