Abstract
Microbial pathway engineering has made significant progress in multiple areas. Many examples of successful pathway engineering for specialty and fine chemicals have been reported in the past two years. Novel carotenoids and polyketides have been synthesized using molecular evolution and combinatorial strategies. In addition, rational design approaches based on metabolic control have been reported to increase metabolic flux to specific products. Experimental and computational tools have been developed to aid in design, reconstruction and analysis of non-native pathways. It is expected that a hybrid of evolutionary, combinatorial and rational design approaches will yield significant advances in the near future.
| Original language | English |
|---|---|
| Pages (from-to) | 330-335 |
| Number of pages | 6 |
| Journal | Current Opinion in Microbiology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 Jun 15 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology
- Infectious Diseases
Cite this
Microbial pathway engineering for industrial processes : Evolution, combinatorial biosynthesis and rational design. / Rohlin, Lars; Oh, Min-Kyu; Liao, James C.
In: Current Opinion in Microbiology, Vol. 4, No. 3, 15.06.2001, p. 330-335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microbial pathway engineering for industrial processes
T2 - Evolution, combinatorial biosynthesis and rational design
AU - Rohlin, Lars
AU - Oh, Min-Kyu
AU - Liao, James C.
PY - 2001/6/15
Y1 - 2001/6/15
N2 - Microbial pathway engineering has made significant progress in multiple areas. Many examples of successful pathway engineering for specialty and fine chemicals have been reported in the past two years. Novel carotenoids and polyketides have been synthesized using molecular evolution and combinatorial strategies. In addition, rational design approaches based on metabolic control have been reported to increase metabolic flux to specific products. Experimental and computational tools have been developed to aid in design, reconstruction and analysis of non-native pathways. It is expected that a hybrid of evolutionary, combinatorial and rational design approaches will yield significant advances in the near future.
AB - Microbial pathway engineering has made significant progress in multiple areas. Many examples of successful pathway engineering for specialty and fine chemicals have been reported in the past two years. Novel carotenoids and polyketides have been synthesized using molecular evolution and combinatorial strategies. In addition, rational design approaches based on metabolic control have been reported to increase metabolic flux to specific products. Experimental and computational tools have been developed to aid in design, reconstruction and analysis of non-native pathways. It is expected that a hybrid of evolutionary, combinatorial and rational design approaches will yield significant advances in the near future.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034986950&partnerID=8YFLogxK
U2 - 10.1016/S1369-5274(00)00213-7
DO - 10.1016/S1369-5274(00)00213-7
M3 - Article
C2 - 11378488
AN - SCOPUS:0034986950
VL - 4
SP - 330
EP - 335
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 3
ER -