Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Je Won Park; Sung Ryeol Park; Ah Reum Han; Yeon Hee Ban; Young Ji Yoo; Eun Ji Kim; Eunji Kim; Yeo Joon Yoon

doi:10.1021/np1006718

Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Je Won Park, Sung Ryeol Park, Ah Reum Han, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Yeo Joon Yoon

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1272-1274
Number of pages	3
Journal	Journal of Natural Products
Volume	74
Issue number	5
DOIs	https://doi.org/10.1021/np1006718
Publication status	Published - 2011 May 27
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np1006718

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title = "Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A",

abstract = "A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).",

author = "Park, {Je Won} and Park, {Sung Ryeol} and Han, {Ah Reum} and Ban, {Yeon Hee} and Yoo, {Young Ji} and Kim, {Eun Ji} and Eunji Kim and Yoon, {Yeo Joon}",

year = "2011",

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doi = "10.1021/np1006718",

language = "English",

volume = "74",

pages = "1272--1274",

journal = "Journal of Natural Products",

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T1 - Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

AU - Park, Je Won

AU - Park, Sung Ryeol

AU - Han, Ah Reum

AU - Ban, Yeon Hee

AU - Yoo, Young Ji

AU - Kim, Eun Ji

AU - Kim, Eunji

AU - Yoon, Yeo Joon

PY - 2011/5/27

Y1 - 2011/5/27

N2 - A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).

AB - A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).

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U2 - 10.1021/np1006718

DO - 10.1021/np1006718

M3 - Article

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AN - SCOPUS:79957853310

SN - 0163-3864

VL - 74

SP - 1272

EP - 1274

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Abstract

ASJC Scopus subject areas

UN SDGs

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