Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Je Won Park, Sung Ryeol Park, Ah Reum Han, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Yeo Joon Yoon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)1272-1274
Number of pages3
JournalJournal of Natural Products
Volume74
Issue number5
DOIs
Publication statusPublished - 2011 May 27

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A'. Together they form a unique fingerprint.

  • Cite this

    Park, J. W., Park, S. R., Han, A. R., Ban, Y. H., Yoo, Y. J., Kim, E. J., Kim, E., & Yoon, Y. J. (2011). Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. Journal of Natural Products, 74(5), 1272-1274. https://doi.org/10.1021/np1006718