Microencapsulation of insulin microcrystals

Sung Hee Choi; Jai Hyun Kwon; Chan Wha Kim

doi:10.1271/bbb.68.749

Microencapsulation of insulin microcrystals

Sung Hee Choi, Jai Hyun Kwon, Chan Wha Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Insulin microcrystals were encapsulated (microcrystal/PLGA) within poly(lactide-co-glycolide) (PLGA 50:50) by the multiple emulsification solvent evaporation technique and compared with insulin solution microspheres (solution/PLGA) in terms of their morphology, size distribution, drug content, encapsulation efficiency, and stability of insulin during release.

Original language	English
Pages (from-to)	749-752
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	68
Issue number	3
DOIs	https://doi.org/10.1271/bbb.68.749
Publication status	Published - 2004 Mar

Keywords

Insulin
Microcrystal
Microsphere
Poly (lactide-co-glycolide) (PLGA)
Stability

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.68.749

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title = "Microencapsulation of insulin microcrystals",

abstract = "Insulin microcrystals were encapsulated (microcrystal/PLGA) within poly(lactide-co-glycolide) (PLGA 50:50) by the multiple emulsification solvent evaporation technique and compared with insulin solution microspheres (solution/PLGA) in terms of their morphology, size distribution, drug content, encapsulation efficiency, and stability of insulin during release.",

keywords = "Insulin, Microcrystal, Microsphere, Poly (lactide-co-glycolide) (PLGA), Stability",

author = "Choi, {Sung Hee} and Kwon, {Jai Hyun} and Kim, {Chan Wha}",

note = "Funding Information: This work was financially supported by the Korean Ministry of Commerce, Industry, and Energy as an industrial and technological development project. Sung Hee Choi and Jai-Hyun Kwon have each been awarded a Brain Korea 21 fellowship from the Korean Ministry of Education & Human Resources Development.",

year = "2004",

month = mar,

doi = "10.1271/bbb.68.749",

language = "English",

volume = "68",

pages = "749--752",

journal = "Bioscience, Biotechnology and Biochemistry",

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number = "3",

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T1 - Microencapsulation of insulin microcrystals

AU - Choi, Sung Hee

AU - Kwon, Jai Hyun

AU - Kim, Chan Wha

N1 - Funding Information: This work was financially supported by the Korean Ministry of Commerce, Industry, and Energy as an industrial and technological development project. Sung Hee Choi and Jai-Hyun Kwon have each been awarded a Brain Korea 21 fellowship from the Korean Ministry of Education & Human Resources Development.

PY - 2004/3

Y1 - 2004/3

N2 - Insulin microcrystals were encapsulated (microcrystal/PLGA) within poly(lactide-co-glycolide) (PLGA 50:50) by the multiple emulsification solvent evaporation technique and compared with insulin solution microspheres (solution/PLGA) in terms of their morphology, size distribution, drug content, encapsulation efficiency, and stability of insulin during release.

AB - Insulin microcrystals were encapsulated (microcrystal/PLGA) within poly(lactide-co-glycolide) (PLGA 50:50) by the multiple emulsification solvent evaporation technique and compared with insulin solution microspheres (solution/PLGA) in terms of their morphology, size distribution, drug content, encapsulation efficiency, and stability of insulin during release.

KW - Insulin

KW - Microcrystal

KW - Microsphere

KW - Poly (lactide-co-glycolide) (PLGA)

KW - Stability

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U2 - 10.1271/bbb.68.749

DO - 10.1271/bbb.68.749

M3 - Article

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AN - SCOPUS:4544289482

SN - 0916-8451

VL - 68

SP - 749

EP - 752

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 3

ER -

Microencapsulation of insulin microcrystals

Abstract

Keywords

ASJC Scopus subject areas

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