This work describes the intimate fusion of microsystems and physiology though the partial implantation of a microfluidic device into living insects, Manduca Sexta moth. This effort is a critical component in our development of "Insect-Micro Air Vehicles (I-MAVs)" which aim to fuse nanodevice technology with living organism. The specific goal of this system is to provide "on-command" chemically induced immobilization and subsequent reanimation of the otherwise autonomous insect by implanting a low power electrokinetic drug delivery device. In this paper, we demonstrate the locomotor activity control by releasing neurotransmitters into wing muscles. We also provide results of our fully functioning adult survivability data for pupal stage implanted microdevices along with results from a comprehensive study of a low power electroactive drug delivery system.