Microfluidic device based biodegradable microfiber scaffold fabrication for tissue engineering application

Chang Mo Hwang, Kyung Sun, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we developed microfluidic chip-based fiber spinning of poly(lactic-coglycolic acid). To make the poly glycolic-co-lactic acid(PLGA) micro fiber, the micro-channel based polydimetylsiloxane(PDMS) spinning device was fabricated, PLGA solution in dimethylsulfoxide (DMSO) and aqueous glycerol solution was used for fiber spinning. By controlling the sample and sheath flow condition, fiber could be made with various diameter from about 20um to 220um. PLGA fibers have dense surface morphology with few surface pore, whereas inside the fiber, highly porous structure with interconnected pores. In cell culture assay for tissue engineering scaffolds, cells were aligned along the fiber axis after 72 hr culture and no evidence of cytotoxic effect induced by the process.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages778-780
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • PDMS microfluidic chip
  • Phase inversion
  • PLGA microfiber
  • Tissue engineering scaffold

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint Dive into the research topics of 'Microfluidic device based biodegradable microfiber scaffold fabrication for tissue engineering application'. Together they form a unique fingerprint.

  • Cite this

    Hwang, C. M., Sun, K., & Lee, S. H. (2007). Microfluidic device based biodegradable microfiber scaffold fabrication for tissue engineering application. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 778-780). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.