TY - GEN
T1 - Microfluidic device based biodegradable microfiber scaffold fabrication for tissue engineering application
AU - Hwang, Chang Mo
AU - Sun, Kyung
AU - Lee, Sang Hoon
N1 - Funding Information:
This research was supported by a grant(Code # : M103KV010031-07K2201-03110) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, and the Korea Health 21 R&D Project(A020609), Ministry of Health and Welfare, the Republic of Korea.
Publisher Copyright:
© 2007 CBMS.
PY - 2007
Y1 - 2007
N2 - In this paper, we developed microfluidic chip-based fiber spinning of poly(lactic-coglycolic acid). To make the poly glycolic-co-lactic acid(PLGA) micro fiber, the micro-channel based polydimetylsiloxane(PDMS) spinning device was fabricated, PLGA solution in dimethylsulfoxide (DMSO) and aqueous glycerol solution was used for fiber spinning. By controlling the sample and sheath flow condition, fiber could be made with various diameter from about 20um to 220um. PLGA fibers have dense surface morphology with few surface pore, whereas inside the fiber, highly porous structure with interconnected pores. In cell culture assay for tissue engineering scaffolds, cells were aligned along the fiber axis after 72 hr culture and no evidence of cytotoxic effect induced by the process.
AB - In this paper, we developed microfluidic chip-based fiber spinning of poly(lactic-coglycolic acid). To make the poly glycolic-co-lactic acid(PLGA) micro fiber, the micro-channel based polydimetylsiloxane(PDMS) spinning device was fabricated, PLGA solution in dimethylsulfoxide (DMSO) and aqueous glycerol solution was used for fiber spinning. By controlling the sample and sheath flow condition, fiber could be made with various diameter from about 20um to 220um. PLGA fibers have dense surface morphology with few surface pore, whereas inside the fiber, highly porous structure with interconnected pores. In cell culture assay for tissue engineering scaffolds, cells were aligned along the fiber axis after 72 hr culture and no evidence of cytotoxic effect induced by the process.
KW - PDMS microfluidic chip
KW - PLGA microfiber
KW - Phase inversion
KW - Tissue engineering scaffold
UR - http://www.scopus.com/inward/record.url?scp=85088677555&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85088677555
T3 - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
SP - 778
EP - 780
BT - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
A2 - Viovy, Jean-Louis
A2 - Tabeling, Patrick
A2 - Descroix, Stephanie
A2 - Malaquin, Laurent
PB - Chemical and Biological Microsystems Society
T2 - 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Y2 - 7 October 2007 through 11 October 2007
ER -