Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

Ioannis K. Zervantonakis, Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, Roger D. Kamm

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.

Original languageEnglish
Article number013406
JournalBiomicrofluidics
Volume5
Issue number1
DOIs
Publication statusPublished - 2011 Mar 23

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Lab-On-A-Chip Devices
microfluidic devices
Microfluidics
Cell Communication
Tissue
tissue engineering
Assays
cells
Cells
Cellular Microenvironment
Preclinical Drug Evaluations
drugs
screening
platforms
interactions
Tissue Engineering
Tissue engineering
Population
Screening
Throughput

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Condensed Matter Physics
  • Materials Science(all)
  • Physical and Theoretical Chemistry

Cite this

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. / Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R.; Chung, Seok; Sudo, Ryo; Kamm, Roger D.

In: Biomicrofluidics, Vol. 5, No. 1, 013406, 23.03.2011.

Research output: Contribution to journalArticle

Zervantonakis, Ioannis K. ; Kothapalli, Chandrasekhar R. ; Chung, Seok ; Sudo, Ryo ; Kamm, Roger D. / Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. In: Biomicrofluidics. 2011 ; Vol. 5, No. 1.
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