Abstract
The development of photo-triggered drug delivery system is promising for the temporal and spatial control of drug release. However, most of the progress in photothermal drug delivery has been focused on nanosized particles which can be removed from the injected sites by exocytosis. In this study, injectable and implantable near-infrared (NIR) light-responsive microparticles are fabricated using droplet-based microfluidics. The particles are composed of 1-tetradecanol, as a class of non-toxic phase change material, and IR780, as a NIR-absorbing photothermal agent. Doxorubicin, an anticancer drug, is encapsulated in the particles to obtain NIR light-responsive anticancer drug carriers. The photothermal response of IR780 to NIR irradiation facilitates the release of the encapsulated drug through the melting of 1-tetradecanol and demonstrates the NIR light-responsive drug release. This study shows that IR780-encapsulated 1-tetradecanol microparticles fabricated by droplet-based microfluidics have great potential as injectable and implantable drug carriers featuring NIR light-sensitive drug release.
| Original language | English |
|---|---|
| Journal | Journal of Industrial and Engineering Chemistry |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
Fingerprint
Keywords
- 1-tetradecanol
- Droplet-based microfluidics
- IR780
- Microparticles
- NIR light-triggered drug release
- Phase change material
ASJC Scopus subject areas
- Chemical Engineering(all)
Cite this
Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release. / Kim, Hyeon Ung; Roh, Yoon Ho; Shim, Min Suk; Bong, Ki Wan.
In: Journal of Industrial and Engineering Chemistry, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microfluidic fabrication of fatty alcohol-based microparticles for NIR light-triggered drug release
AU - Kim, Hyeon Ung
AU - Roh, Yoon Ho
AU - Shim, Min Suk
AU - Bong, Ki Wan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The development of photo-triggered drug delivery system is promising for the temporal and spatial control of drug release. However, most of the progress in photothermal drug delivery has been focused on nanosized particles which can be removed from the injected sites by exocytosis. In this study, injectable and implantable near-infrared (NIR) light-responsive microparticles are fabricated using droplet-based microfluidics. The particles are composed of 1-tetradecanol, as a class of non-toxic phase change material, and IR780, as a NIR-absorbing photothermal agent. Doxorubicin, an anticancer drug, is encapsulated in the particles to obtain NIR light-responsive anticancer drug carriers. The photothermal response of IR780 to NIR irradiation facilitates the release of the encapsulated drug through the melting of 1-tetradecanol and demonstrates the NIR light-responsive drug release. This study shows that IR780-encapsulated 1-tetradecanol microparticles fabricated by droplet-based microfluidics have great potential as injectable and implantable drug carriers featuring NIR light-sensitive drug release.
AB - The development of photo-triggered drug delivery system is promising for the temporal and spatial control of drug release. However, most of the progress in photothermal drug delivery has been focused on nanosized particles which can be removed from the injected sites by exocytosis. In this study, injectable and implantable near-infrared (NIR) light-responsive microparticles are fabricated using droplet-based microfluidics. The particles are composed of 1-tetradecanol, as a class of non-toxic phase change material, and IR780, as a NIR-absorbing photothermal agent. Doxorubicin, an anticancer drug, is encapsulated in the particles to obtain NIR light-responsive anticancer drug carriers. The photothermal response of IR780 to NIR irradiation facilitates the release of the encapsulated drug through the melting of 1-tetradecanol and demonstrates the NIR light-responsive drug release. This study shows that IR780-encapsulated 1-tetradecanol microparticles fabricated by droplet-based microfluidics have great potential as injectable and implantable drug carriers featuring NIR light-sensitive drug release.
KW - 1-tetradecanol
KW - Droplet-based microfluidics
KW - IR780
KW - Microparticles
KW - NIR light-triggered drug release
KW - Phase change material
UR - http://www.scopus.com/inward/record.url?scp=85069595807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069595807&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2019.06.047
DO - 10.1016/j.jiec.2019.06.047
M3 - Article
AN - SCOPUS:85069595807
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
ER -