Microfluidic model for endothelial to mesenchymal transition (ENDMT) induced by melanoma-derived exosomes

Ju Hun Yeon, Hyo Eun Jeong, Hyemin Seo, Siwoo Cho, Youhee Heo, Jaesung Park, Seok Chung, Nakwon Choi, Ji Yoon Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Melanoma-derived exosomes have been known to play a significant role in the formation of tumor environment by initiating angiogenic processes and triggering metastatic evolution [1]. Recent studies have reported that the melanoma-derived exosomes triggered endothelial to mesenchymal transition (EndMT); this cellular transition induced the differentiation of endothelial cells to cancer-associated fibroblasts (CAFs) to remodel extracellular matrix (ECM) and increased the expression level of transforming growth factor beta (TGF-β) [2, 3]. However, an enabling tool in vitro is yet to be developed in order to investigate how cancer-derived exosomes induce the EndMT and cause the differentiation of endothelial cells to the CAFs. Here we suggest an in vitro microfluidic model that allows for monitoring a synergetic effect of both interstitial flow and the melanoma-derived exosomes on the EndMT.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages105-107
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Keywords

  • CAFs
  • EndMT
  • Exosome
  • Interstitial flow
  • Melanoma
  • Microfluidic model

ASJC Scopus subject areas

  • Control and Systems Engineering

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