Microfluidic platforms for the study of cancer metastasis

Juan Lin Ng, Yoojin Shin, Seok Chung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Metastases many a time leave cancer patients untreatable and are one of the leading causes of death worldwide. Microfluidic platforms are arguably the most suitable for the study of cancer metastasis given its ability to mimic in vivo microenvironment of cancer tumor by manipulating its mechanical properties. This review discusses some applications of microfluidic platforms and their advantages for cancer biology and pathology. Studies of cancer metastasis conducted on its compositional steps enable us to elucidate elementary mechanisms through disease modeling. From that, communication and interaction of cancer cells, cellular metabolism related issues, and ultimately cancer drug discovery and delivery are manipulated on microfluidic platforms.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalBiomedical Engineering Letters
Volume2
Issue number2
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Microfluidics
Pathology
Drug delivery
Metabolism
Tumors
Cells
Mechanical properties
Communication

Keywords

  • Cancer metastasis
  • Microenvironment
  • Microfluidics

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Microfluidic platforms for the study of cancer metastasis. / Ng, Juan Lin; Shin, Yoojin; Chung, Seok.

In: Biomedical Engineering Letters, Vol. 2, No. 2, 01.12.2012, p. 72-77.

Research output: Contribution to journalArticle

Ng, Juan Lin ; Shin, Yoojin ; Chung, Seok. / Microfluidic platforms for the study of cancer metastasis. In: Biomedical Engineering Letters. 2012 ; Vol. 2, No. 2. pp. 72-77.
@article{d21e4acf0d8149548f9164341fae086a,
title = "Microfluidic platforms for the study of cancer metastasis",
abstract = "Metastases many a time leave cancer patients untreatable and are one of the leading causes of death worldwide. Microfluidic platforms are arguably the most suitable for the study of cancer metastasis given its ability to mimic in vivo microenvironment of cancer tumor by manipulating its mechanical properties. This review discusses some applications of microfluidic platforms and their advantages for cancer biology and pathology. Studies of cancer metastasis conducted on its compositional steps enable us to elucidate elementary mechanisms through disease modeling. From that, communication and interaction of cancer cells, cellular metabolism related issues, and ultimately cancer drug discovery and delivery are manipulated on microfluidic platforms.",
keywords = "Cancer metastasis, Microenvironment, Microfluidics",
author = "Ng, {Juan Lin} and Yoojin Shin and Seok Chung",
year = "2012",
month = "12",
day = "1",
doi = "10.1007/s13534-012-0055-x",
language = "English",
volume = "2",
pages = "72--77",
journal = "Biomedical Engineering Letters",
issn = "2093-9868",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Microfluidic platforms for the study of cancer metastasis

AU - Ng, Juan Lin

AU - Shin, Yoojin

AU - Chung, Seok

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Metastases many a time leave cancer patients untreatable and are one of the leading causes of death worldwide. Microfluidic platforms are arguably the most suitable for the study of cancer metastasis given its ability to mimic in vivo microenvironment of cancer tumor by manipulating its mechanical properties. This review discusses some applications of microfluidic platforms and their advantages for cancer biology and pathology. Studies of cancer metastasis conducted on its compositional steps enable us to elucidate elementary mechanisms through disease modeling. From that, communication and interaction of cancer cells, cellular metabolism related issues, and ultimately cancer drug discovery and delivery are manipulated on microfluidic platforms.

AB - Metastases many a time leave cancer patients untreatable and are one of the leading causes of death worldwide. Microfluidic platforms are arguably the most suitable for the study of cancer metastasis given its ability to mimic in vivo microenvironment of cancer tumor by manipulating its mechanical properties. This review discusses some applications of microfluidic platforms and their advantages for cancer biology and pathology. Studies of cancer metastasis conducted on its compositional steps enable us to elucidate elementary mechanisms through disease modeling. From that, communication and interaction of cancer cells, cellular metabolism related issues, and ultimately cancer drug discovery and delivery are manipulated on microfluidic platforms.

KW - Cancer metastasis

KW - Microenvironment

KW - Microfluidics

UR - http://www.scopus.com/inward/record.url?scp=84876964154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876964154&partnerID=8YFLogxK

U2 - 10.1007/s13534-012-0055-x

DO - 10.1007/s13534-012-0055-x

M3 - Article

VL - 2

SP - 72

EP - 77

JO - Biomedical Engineering Letters

JF - Biomedical Engineering Letters

SN - 2093-9868

IS - 2

ER -