Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Chang Mo Hwang, K. Sun, A. Khademhosseini, S. H. Lee

Research output: Contribution to conferencePaperpeer-review

Abstract

This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

Original languageEnglish
Pages131-133
Number of pages3
Publication statusPublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/TerritoryUnited States
CitySan Diego, CA
Period08/10/1208/10/16

Keywords

  • Biodegradable polymer
  • Cell alignment
  • Microfluidic spinning

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint

Dive into the research topics of 'Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers'. Together they form a unique fingerprint.

Cite this