Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Chang Mo Hwang; K. Sun; A. Khademhosseini; S. H. Lee

Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Chang Mo Hwang, K. Sun, A. Khademhosseini, S. H. Lee

Department of Bio-convergence Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

Original language	English
Pages	131-133
Number of pages	3
Publication status	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 2008 Oct 12 → 2008 Oct 16

Other

Other	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	08/10/12 → 08/10/16

Keywords

Biodegradable polymer
Cell alignment
Microfluidic spinning

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers. / Hwang, Chang Mo; Sun, K.; Khademhosseini, A.; Lee, S. H.

2008. 131-133 Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.

Research output: Contribution to conference › Paper › peer-review

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abstract = "This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.",

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AU - Hwang, Chang Mo

AU - Sun, K.

AU - Khademhosseini, A.

AU - Lee, S. H.

PY - 2008

Y1 - 2008

N2 - This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

AB - This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

KW - Biodegradable polymer

KW - Cell alignment

KW - Microfluidic spinning

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M3 - Paper

AN - SCOPUS:84902506255

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T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Abstract

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Keywords

ASJC Scopus subject areas

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