Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Chang Mo Hwang; Kyung Sun; A. Khademhosseini; Sang Hoon Lee

Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers

Chang Mo Hwang, Kyung Sun, A. Khademhosseini, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

Original language	English
Title of host publication	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
Publisher	Chemical and Biological Microsystems Society
Pages	131-133
Number of pages	3
Publication status	Published - 2008 Jan 1
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 2008 Oct 12 → 2008 Oct 16

Other

Other	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country	United States
City	San Diego, CA
Period	08/10/12 → 08/10/16

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

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Cite this

Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers. / Hwang, Chang Mo; Sun, Kyung; Khademhosseini, A.; Lee, Sang Hoon.

12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, 2008. p. 131-133.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hwang, CM, Sun, K, Khademhosseini, A & Lee, SH 2008, Microfluidic spinning of biodegradable polymer and cell orientation control on the fibers. in 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, pp. 131-133, 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States, 08/10/12.

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abstract = "This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.",

keywords = "Biodegradable polymer, Cell alignment, Microfluidic spinning",

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N2 - This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

AB - This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibroblast cells were cultured on the surface of the fibers and the result showed unique tendency of cell orientation on the fibers.

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