Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds

Edward Kang, Yoon Young Choi, Su Kyoung Chae, Jin Hee Moon, Joon Young Chang, Sang Hoon Lee

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)

Abstract

Alginate microribbons with longitudinally grooved microstructures are continuously fabricated by means of a microfluidic system. The number and dimensions of the microgroovesare successfully controlled by regulation of the slit-shaped channel (yellow in figure). This method opens up the possibility of mass production of scaffolds for tissue engineering purposes, as it is proved that the grooved flat fibers can be used to align other types of cells in culture.

Original languageEnglish
Pages (from-to)4271-4277
Number of pages7
JournalAdvanced Materials
Volume24
Issue number31
DOIs
Publication statusPublished - 2012 Aug 16

Keywords

  • alginates
  • cell alignment
  • fibers
  • grooved
  • microfluidic spinning
  • microstructures
  • patterned
  • ribbons

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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