Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells

Yoojin Shin, Sewoon Han, Hyunju Kim, Jae Hong Kim, Roger D. Kamm, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages353-355
Number of pages3
Publication statusPublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Cancer metastasis
  • Extracelluar Matrix (ECM)
  • Microfluidics
  • Three-dimensional migration

ASJC Scopus subject areas

  • Control and Systems Engineering

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