TY - GEN
T1 - Microfluidic study on ECM-dependent three dimensional morphogenesis of breast adenocarcinoma cells
AU - Shin, Yoojin
AU - Han, Sewoon
AU - Kim, Hyunju
AU - Kim, Jae Hong
AU - Kamm, Roger D.
AU - Chung, Seok
PY - 2011
Y1 - 2011
N2 - When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.
AB - When cancer cells move from original site to other parts of body by dissemination throughout blood vessel and lymphatic vessel, it is termed cancer metastasis. Cancer metastasis is complex and three-dimensional(3D) process integrated with various oncogenes, growth factors and interactions with stroma (stromal cells and surrounding ECM)[1]. In this paper, we have focused on the interaction between 3D ECM microenvironment and cancer cells by introducing various types of hydrogel in microfluidic system. Cancer cells showed various morphologies while invading into various types of ECM.
KW - Cancer metastasis
KW - Extracelluar Matrix (ECM)
KW - Microfluidics
KW - Three-dimensional migration
UR - http://www.scopus.com/inward/record.url?scp=84883767406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883767406&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883767406
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 353
EP - 355
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -
