Microfluidic synthesis of functional polymeric particles for cell capture and isolation

Ramin Haghgooie, Mehmet Toner, Ki Wan Bong, Patrick S. Doyle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate a method, based upon photopolymerization in microfluidic devices, to synthesize polymeric hydrogel microparticles with anisotropic shape and chemistry for cell capture. We discuss means of particle synthesis and characterization of the ability to capture cells in buffer. The size and shape of the particles are dictated by a photolithographic mask and geometry of the microchannel, allowing automated production of complex shapes. The functional properties of the particles are tuned by altering their chemistry independent of the shape and size. The particles are functionalized with an antibody against cell surface proteins which is then used to capture specific target cells.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1596-1598
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Bio-compatible
  • Cell-capture
  • Hydrogels
  • Photopolymerization

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Haghgooie, R., Toner, M., Bong, K. W., & Doyle, P. S. (2009). Microfluidic synthesis of functional polymeric particles for cell capture and isolation. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1596-1598). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.