Microfluidic system for 3D cell invasion study

Yoojin Shin, Hyunju Kim, Jessie S. Jeon, Geun Young Kim, Juonghun Nam, Seungha Lee, Sehyun Shin, Jae-Hong Kim, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cancer metastasis is a three-dimensional (3D) process which cancer cells in primary sites move toward other parts of human body. Recent studies have focused on understanding cancer cell invasion to inhibit the initiation of cancer cell migration and intravasation to finally prevent cancer metastasis over all. Therefore, it is important to understand the roles of many biochemical and biophysical factors on cancer cell invasion2-3. We have developed a novel microfluidic system to provide physiological 3D micro environment in vitro4 and applied the system to accurately evaluate the role of the factors for cancer cell invasion in 3D interacting extracellular matrix.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages953-955
Number of pages3
Volume2
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Keywords

  • Cancer metastasis
  • Cell invasion
  • Cell-on-a-chip
  • Microfluidics

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Shin, Y., Kim, H., Jeon, J. S., Kim, G. Y., Nam, J., Lee, S., Shin, S., Kim, J-H., & Chung, S. (2010). Microfluidic system for 3D cell invasion study. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 2, pp. 953-955)