Abstract
Cancer metastasis is a three-dimensional (3D) process which cancer cells in primary sites move toward other parts of human body. Recent studies have focused on understanding cancer cell invasion to inhibit the initiation of cancer cell migration and intravasation to finally prevent cancer metastasis over all. Therefore, it is important to understand the roles of many biochemical and biophysical factors on cancer cell invasion2-3. We have developed a novel microfluidic system to provide physiological 3D micro environment in vitro4 and applied the system to accurately evaluate the role of the factors for cancer cell invasion in 3D interacting extracellular matrix.
| Original language | English |
|---|---|
| Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
| Pages | 953-955 |
| Number of pages | 3 |
| Volume | 2 |
| Publication status | Published - 2010 Dec 1 |
| Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: 2010 Oct 3 → 2010 Oct 7 |
Other
| Other | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Country | Netherlands |
| City | Groningen |
| Period | 10/10/3 → 10/10/7 |
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Keywords
- Cancer metastasis
- Cell invasion
- Cell-on-a-chip
- Microfluidics
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Microfluidic system for 3D cell invasion study. / Shin, Yoojin; Kim, Hyunju; Jeon, Jessie S.; Kim, Geun Young; Nam, Juonghun; Lee, Seungha; Shin, Sehyun; Kim, Jae-Hong; Chung, Seok.
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 2 2010. p. 953-955.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Microfluidic system for 3D cell invasion study
AU - Shin, Yoojin
AU - Kim, Hyunju
AU - Jeon, Jessie S.
AU - Kim, Geun Young
AU - Nam, Juonghun
AU - Lee, Seungha
AU - Shin, Sehyun
AU - Kim, Jae-Hong
AU - Chung, Seok
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Cancer metastasis is a three-dimensional (3D) process which cancer cells in primary sites move toward other parts of human body. Recent studies have focused on understanding cancer cell invasion to inhibit the initiation of cancer cell migration and intravasation to finally prevent cancer metastasis over all. Therefore, it is important to understand the roles of many biochemical and biophysical factors on cancer cell invasion2-3. We have developed a novel microfluidic system to provide physiological 3D micro environment in vitro4 and applied the system to accurately evaluate the role of the factors for cancer cell invasion in 3D interacting extracellular matrix.
AB - Cancer metastasis is a three-dimensional (3D) process which cancer cells in primary sites move toward other parts of human body. Recent studies have focused on understanding cancer cell invasion to inhibit the initiation of cancer cell migration and intravasation to finally prevent cancer metastasis over all. Therefore, it is important to understand the roles of many biochemical and biophysical factors on cancer cell invasion2-3. We have developed a novel microfluidic system to provide physiological 3D micro environment in vitro4 and applied the system to accurately evaluate the role of the factors for cancer cell invasion in 3D interacting extracellular matrix.
KW - Cancer metastasis
KW - Cell invasion
KW - Cell-on-a-chip
KW - Microfluidics
UR - http://www.scopus.com/inward/record.url?scp=84884390037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884390037&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84884390037
SN - 9781618390622
VL - 2
SP - 953
EP - 955
BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
ER -