Microinflammation in hemodialysis patients is associated with increased CD14+CD16+ pro-inflammatory monocytes: Possible modification by on-line hemodiafiltration

Hye Won Kim, Ha Na Yang, Myung Gyu Kim, Hye Min Choi, Sang Kyung Jo, Won Yong Cho, Hyoung Kyu Kim

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Background: An increased percentage of pro-inflammatory CD14 +CD16+ monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (HDF). Methods: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-α. Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusion: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients, and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response.

    Original languageEnglish
    Pages (from-to)281-288
    Number of pages8
    JournalBlood Purification
    Volume31
    Issue number4
    DOIs
    Publication statusPublished - 2011 Jun

    Keywords

    • Chronic inflammation
    • Hemodialysis
    • Monocytes
    • On-line hemodiafiltration
    • Tumor necrosis factor

    ASJC Scopus subject areas

    • Hematology
    • Nephrology

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