@inproceedings{aa54ff9bfa7a4f68bd3f018882aae69c,
title = "Micromachined ultrasound transducer array for cell stimulation with high spatial resolution",
abstract = "In this work, we present a piezoelectric micromachined ultrasonic transducer (pMUT) array for local stimulation on cultured cells with a high spatial resolution for the first time. We used a bulk piezoelectric film that has a higher piezoelectric coefficient (d31) than that of the thin film materials to achieve high acoustic power within a small membrane. The 500-μm-wide and 55-μm-thick transducer membrane exhibits a resonant frequency of 780 kHz, which is within the effective frequency range for stimulating cells. We also demonstrate successful in vitro experiments by stimulating cells using the fabricated pMUT array and verifying the stimulation using fluorescence calcium imaging. Using fluorescence imaging, we observed an increase in Ca2+ level of TRPA1 expressing HEK293T cells under ultrasound sonication, which confirms that TRPA1 channel in HEK293T cells was activated by ultrasound.",
author = "Kyungmin Ko and Lee, {Jin Hyung} and Lee, {Hyunjoo Jenny} and Oh, {Soo Jin} and Chun, {Ye Eun} and Kim, {Tae Song} and Lee, {C. Justin} and Yoon, {Eui Sung} and Yun, {Kwang Seok} and Cho, {Il Joo}",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 ; Conference date: 18-01-2015 Through 22-01-2015",
year = "2015",
month = feb,
day = "26",
doi = "10.1109/MEMSYS.2015.7051041",
language = "English",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "February",
pages = "651--654",
booktitle = "2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015",
edition = "February",
}