Micromixer as a continuous flow reactor for the synthesis of a pharmaceutical intermediate

Jaehoon Choe, Youngwoon Kwon, Yeongdae Kim, Hyun Seob Song, Kwang Ho Song

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A mixing device composed of a micron scale flow channel was applied as a continuous reactor to control exothermic reaction heat and to increase the product yield, in a synthesis of a pharmaceutical intermediate of quinolone antibiotics. The model reaction featured a fast reaction rate, high heat generation, and impurity formation due to a prolonged contact time between reactants and products. Using the micromixer reactor, the reaction heat was efficiently removed so that virtually no impurities were produced during the reaction. A product yield comparable to the theoretical value was achieved in a single micromixer unit. Optimum operating conditions were acquired from a statistical method by using factorial design, which was also verified by a CFD calculation.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalKorean Journal of Chemical Engineering
Volume20
Issue number2
Publication statusPublished - 2003 Mar 1
Externally publishedYes

Fingerprint

Drug products
Impurities
Exothermic reactions
Quinolones
Heat generation
Antibiotics
Channel flow
Pharmaceutical Preparations
Reaction rates
Statistical methods
Computational fluid dynamics
Anti-Bacterial Agents
Hot Temperature

Keywords

  • Boc
  • Exothermic Reaction
  • Micromixer
  • Microreactor
  • Response Surface Method

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Micromixer as a continuous flow reactor for the synthesis of a pharmaceutical intermediate. / Choe, Jaehoon; Kwon, Youngwoon; Kim, Yeongdae; Song, Hyun Seob; Song, Kwang Ho.

In: Korean Journal of Chemical Engineering, Vol. 20, No. 2, 01.03.2003, p. 268-272.

Research output: Contribution to journalArticle

Choe, Jaehoon ; Kwon, Youngwoon ; Kim, Yeongdae ; Song, Hyun Seob ; Song, Kwang Ho. / Micromixer as a continuous flow reactor for the synthesis of a pharmaceutical intermediate. In: Korean Journal of Chemical Engineering. 2003 ; Vol. 20, No. 2. pp. 268-272.
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