Micropatterning of cardiomyocytes using adhesion-resistant polymeric microstructures

Deok Ho Kim, Kahp Y. Suh, Pilnam Kim, Seung Kyu Choi, Sang Ho Lee, Byungkyu Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work describes a simple approach to patterned growth of cardiomyocytes with high activity aided by three-dimensional physical barrier of polyethylene glycol (PEG) microstructures. The morphology and mobility of patterned cardiomyocytes were analyzed with different topographical heights of the PEG barrier. It was found that isolated aggregates of cardiomyocytes showed various beating activities depending on the morphology and the number of cells. Furthermore, three-dimensionally grown cardiac muscle cells medicated by a higher physical barrier generated higher contraction force with faster beating frequency than those of cells attached to the collagen-coated surface on culture dish (control), suggesting that control over cell growth and shape would be critical for optimizing the activity and functions of patterned cardiomyocytes.

Original languageEnglish
Title of host publicationDigest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Pages1664-1667
Number of pages4
Volume2
Publication statusPublished - 2005 Nov 9
Event13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of
Duration: 2005 Jun 52005 Jun 9

Other

Other13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
CountryKorea, Republic of
CitySeoul
Period05/6/505/6/9

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kim, D. H., Suh, K. Y., Kim, P., Choi, S. K., Lee, S. H., & Kim, B. (2005). Micropatterning of cardiomyocytes using adhesion-resistant polymeric microstructures. In Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05 (Vol. 2, pp. 1664-1667). [3E4.92]