Micropatterning of diacetylenic liposomes on glass surfaces

Hee Yong Shim, Sang Hoon Lee, Dong June Ahn, Kwang Duk Ahn, Jong Man Kim

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We report the results on the immobilization of polydiacetylene liposomes on glass substrates obtained by the use of micro-contact printing (μCP) technique. Micro-patterned self-assembled monolayer of 3-aminopropyltriethoxysilane (APS) was formed at contact regions of a polydimethylsiloxane (PDMS) stamp with the clean glass surfaces. Polydiacetylene liposomes were then covalently attached to the APS regions, by amidization between surface amine groups of the pattern and N -hydroxy succinimide moieties of the liposomes. Fluorescence images revealed that the polydiacetylene liposomes were successfully immobilized on glasses forming patterns of squares with a width of 70 μm and dots with diameters of 15 to 50 μm. The results would be potentially useful for developing stable liposome-array sensors based on glasses.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalMaterials Science and Engineering C
Volume24
Issue number1-2
DOIs
Publication statusPublished - 2004 Jan 5

Keywords

  • Fluorescence
  • Liposomes
  • Micro-contact printing
  • Micro-pattern
  • Polydiacetylene

ASJC Scopus subject areas

  • Biomaterials

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