microRNA Let-7b: A Novel treatment for endometriosis

Cagdas Sahin, Ramanaiah Mamillapalli, Kyong W. Yi, Hugh S. Taylor

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Endometriosis is an oestrogen-dependent, chronic inflammatory disease that affects 10% of reproductive-aged women. Current treatment options depend on female sex steroid hormone modulation; however, all have side effects and are not useful in women who want to conceive. microRNAs treatments have provided promising results for some chronic diseases and cancers. We have previously shown the microRNA Let-7b is repressed in endometriosis and that loss of Let-7 contributes to the pathophysiology of the disease. Here, we propose using microRNA Let-7b for the treatment of endometriosis in a murine model. Endometriosis was treated using microRNA Let-7b or a scrambled control microRNA. Let-7b treatment resulted in reduced endometriosis lesion size. Decreased gene expression was noted in several genes known to promote endometriosis growth including ER-α, ER-ß, Cyp19a, KRAS 4A, KRAS 4B and IL-6. These results indicate that microRNA Let-7b has a pleiotropic role in endometriosis pathophysiology affecting oestrogen signalling, inflammation and growth factor receptors. Local treatment of endometriosis with Let-7b is a promising therapy for endometriosis that simultaneously affects multiple pathways driving endometriosis without systemic hormonal side effects.

    Original languageEnglish
    Pages (from-to)5346-5353
    Number of pages8
    JournalJournal of Cellular and Molecular Medicine
    Volume22
    Issue number11
    DOIs
    Publication statusPublished - 2018 Nov

    Keywords

    • endometriosis
    • miRNA Let-7b
    • microRNA
    • oligonucleotide treatment

    ASJC Scopus subject areas

    • Molecular Medicine
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'microRNA Let-7b: A Novel treatment for endometriosis'. Together they form a unique fingerprint.

    Cite this