Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer

Young Kyung Lim, Jungwon Kwak, Dong Wook Kim, Dongho Shin, Myonggeun Yoon, Soah Park, Jin Sung Kim, Sung Hwan Ahn, Jungwook Shin, Se Byeong Lee, Sung Yong Park, Hong Ryeol Pyo, Dae Yong Kim, Kwan Ho Cho

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: We examined the feasibility of using fiducial markers composed of microscopic gold particles and human-compatible polymers as a means to overcome current problems with conventional macroscopic gold fiducial markers, such as dose reduction and artifact generation, in proton therapy for prostate cancer. Methods and Materials: We examined two types of gold particle fiducial marker interactions: that with diagnostic X-rays and with a therapeutic proton beam. That is, we qualitatively and quantitatively compared the radiographic visibility of conventional gold and gold particle fiducial markers and the CT artifacts and dose reduction associated with their use. Results: The gold particle fiducials could be easily distinguished from high-density structures, such as the pelvic bone, in diagnostic X-rays but were nearly transparent to a proton beam. The proton dose distribution was distorted <5% by the gold particle fiducials with a 4.9% normalized gold density; this was the case even in the worst configuration (i.e., parallel alignment with a single-direction proton beam). In addition, CT artifacts were dramatically reduced for the gold particle mixture. Conclusion: Mixtures of microscopic gold particles and human-compatible polymers have excellent potential as fiducial markers for proton therapy for prostate cancer. These include good radiographic visibility, low distortion of the depth-dose distribution, and few CT artifacts.

Original languageEnglish
Pages (from-to)1609-1616
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number5
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Fingerprint

Fiducial Markers
Proton Therapy
Gold
markers
therapy
Prostatic Neoplasms
cancer
gold
protons
Artifacts
artifacts
Protons
proton beams
dosage
Radiography
Polymers
low visibility
Pelvic Bones
polymers
visibility

Keywords

  • Fiducial marker
  • Gold particle
  • Prostate cancer
  • Proton therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer. / Lim, Young Kyung; Kwak, Jungwon; Kim, Dong Wook; Shin, Dongho; Yoon, Myonggeun; Park, Soah; Kim, Jin Sung; Ahn, Sung Hwan; Shin, Jungwook; Lee, Se Byeong; Park, Sung Yong; Pyo, Hong Ryeol; Kim, Dae Yong; Cho, Kwan Ho.

In: International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 5, 01.08.2009, p. 1609-1616.

Research output: Contribution to journalArticle

Lim, YK, Kwak, J, Kim, DW, Shin, D, Yoon, M, Park, S, Kim, JS, Ahn, SH, Shin, J, Lee, SB, Park, SY, Pyo, HR, Kim, DY & Cho, KH 2009, 'Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer', International Journal of Radiation Oncology Biology Physics, vol. 74, no. 5, pp. 1609-1616. https://doi.org/10.1016/j.ijrobp.2009.02.076
Lim, Young Kyung ; Kwak, Jungwon ; Kim, Dong Wook ; Shin, Dongho ; Yoon, Myonggeun ; Park, Soah ; Kim, Jin Sung ; Ahn, Sung Hwan ; Shin, Jungwook ; Lee, Se Byeong ; Park, Sung Yong ; Pyo, Hong Ryeol ; Kim, Dae Yong ; Cho, Kwan Ho. / Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer. In: International Journal of Radiation Oncology Biology Physics. 2009 ; Vol. 74, No. 5. pp. 1609-1616.
@article{8c6e36d4c5da45d79247084c82dee48c,
title = "Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer",
abstract = "Purpose: We examined the feasibility of using fiducial markers composed of microscopic gold particles and human-compatible polymers as a means to overcome current problems with conventional macroscopic gold fiducial markers, such as dose reduction and artifact generation, in proton therapy for prostate cancer. Methods and Materials: We examined two types of gold particle fiducial marker interactions: that with diagnostic X-rays and with a therapeutic proton beam. That is, we qualitatively and quantitatively compared the radiographic visibility of conventional gold and gold particle fiducial markers and the CT artifacts and dose reduction associated with their use. Results: The gold particle fiducials could be easily distinguished from high-density structures, such as the pelvic bone, in diagnostic X-rays but were nearly transparent to a proton beam. The proton dose distribution was distorted <5{\%} by the gold particle fiducials with a 4.9{\%} normalized gold density; this was the case even in the worst configuration (i.e., parallel alignment with a single-direction proton beam). In addition, CT artifacts were dramatically reduced for the gold particle mixture. Conclusion: Mixtures of microscopic gold particles and human-compatible polymers have excellent potential as fiducial markers for proton therapy for prostate cancer. These include good radiographic visibility, low distortion of the depth-dose distribution, and few CT artifacts.",
keywords = "Fiducial marker, Gold particle, Prostate cancer, Proton therapy",
author = "Lim, {Young Kyung} and Jungwon Kwak and Kim, {Dong Wook} and Dongho Shin and Myonggeun Yoon and Soah Park and Kim, {Jin Sung} and Ahn, {Sung Hwan} and Jungwook Shin and Lee, {Se Byeong} and Park, {Sung Yong} and Pyo, {Hong Ryeol} and Kim, {Dae Yong} and Cho, {Kwan Ho}",
year = "2009",
month = "8",
day = "1",
doi = "10.1016/j.ijrobp.2009.02.076",
language = "English",
volume = "74",
pages = "1609--1616",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Microscopic Gold Particle-Based Fiducial Markers for Proton Therapy of Prostate Cancer

AU - Lim, Young Kyung

AU - Kwak, Jungwon

AU - Kim, Dong Wook

AU - Shin, Dongho

AU - Yoon, Myonggeun

AU - Park, Soah

AU - Kim, Jin Sung

AU - Ahn, Sung Hwan

AU - Shin, Jungwook

AU - Lee, Se Byeong

AU - Park, Sung Yong

AU - Pyo, Hong Ryeol

AU - Kim, Dae Yong

AU - Cho, Kwan Ho

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Purpose: We examined the feasibility of using fiducial markers composed of microscopic gold particles and human-compatible polymers as a means to overcome current problems with conventional macroscopic gold fiducial markers, such as dose reduction and artifact generation, in proton therapy for prostate cancer. Methods and Materials: We examined two types of gold particle fiducial marker interactions: that with diagnostic X-rays and with a therapeutic proton beam. That is, we qualitatively and quantitatively compared the radiographic visibility of conventional gold and gold particle fiducial markers and the CT artifacts and dose reduction associated with their use. Results: The gold particle fiducials could be easily distinguished from high-density structures, such as the pelvic bone, in diagnostic X-rays but were nearly transparent to a proton beam. The proton dose distribution was distorted <5% by the gold particle fiducials with a 4.9% normalized gold density; this was the case even in the worst configuration (i.e., parallel alignment with a single-direction proton beam). In addition, CT artifacts were dramatically reduced for the gold particle mixture. Conclusion: Mixtures of microscopic gold particles and human-compatible polymers have excellent potential as fiducial markers for proton therapy for prostate cancer. These include good radiographic visibility, low distortion of the depth-dose distribution, and few CT artifacts.

AB - Purpose: We examined the feasibility of using fiducial markers composed of microscopic gold particles and human-compatible polymers as a means to overcome current problems with conventional macroscopic gold fiducial markers, such as dose reduction and artifact generation, in proton therapy for prostate cancer. Methods and Materials: We examined two types of gold particle fiducial marker interactions: that with diagnostic X-rays and with a therapeutic proton beam. That is, we qualitatively and quantitatively compared the radiographic visibility of conventional gold and gold particle fiducial markers and the CT artifacts and dose reduction associated with their use. Results: The gold particle fiducials could be easily distinguished from high-density structures, such as the pelvic bone, in diagnostic X-rays but were nearly transparent to a proton beam. The proton dose distribution was distorted <5% by the gold particle fiducials with a 4.9% normalized gold density; this was the case even in the worst configuration (i.e., parallel alignment with a single-direction proton beam). In addition, CT artifacts were dramatically reduced for the gold particle mixture. Conclusion: Mixtures of microscopic gold particles and human-compatible polymers have excellent potential as fiducial markers for proton therapy for prostate cancer. These include good radiographic visibility, low distortion of the depth-dose distribution, and few CT artifacts.

KW - Fiducial marker

KW - Gold particle

KW - Prostate cancer

KW - Proton therapy

UR - http://www.scopus.com/inward/record.url?scp=67651083727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651083727&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2009.02.076

DO - 10.1016/j.ijrobp.2009.02.076

M3 - Article

C2 - 19616746

AN - SCOPUS:67651083727

VL - 74

SP - 1609

EP - 1616

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 5

ER -