Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Woo Seung Ham, Min Kyung Kim, Ji Seok Gim, Ji Sung Lee, Jun Hua Wu, Kyu Back Lee, Young-geun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x=0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x=0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.

Original languageEnglish
Article number7113860
JournalIEEE Transactions on Magnetics
Volume51
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

Magnetic properties
Nanoparticles
Assays
Microstructure
Curie temperature
Enzymes
Immunosorbents
Troponin I
Polyols
Saturation magnetization
Antigens
Antibodies
Medicine
Crystal structure
Heat treatment
Heating
Temperature

Keywords

  • Cardiac troponin I (cTnI)
  • Curie temperature
  • immunoassay
  • LaSrMnO nanoparticles (NPs)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

Cite this

Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay. / Ham, Woo Seung; Kim, Min Kyung; Gim, Ji Seok; Lee, Ji Sung; Wu, Jun Hua; Lee, Kyu Back; Kim, Young-geun.

In: IEEE Transactions on Magnetics, Vol. 51, No. 11, 7113860, 01.11.2015.

Research output: Contribution to journalArticle

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