Mid-term angiographic benefit of sirolimus-eluting stents compared with paclitaxel-eluting stents in patients with acute myocardial infarction

Cheol Ung Choi, Seung Woon Rha, Kang Yin Chen, Zhe Jin, Yoshiyasu Minami, Seung Yong Shin, Jin Oh Na, Soon Yong Suh, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh

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Abstract

Background: We compared angiographic and clinical outcomes among different drug-eluting stents (DESs) in Korean acute myocardial infarction (AMI) patients. Methods: A total of 109 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) with either sirolimus-eluting (SES, n = 56 pts) or paclitaxel-eluting stents (PES, n = 53 pts) were enrolled from August 2004 to December 2006. The angiographic outcomes at 6 months and clinical outcomes at 1 year were compared between the two groups. Results: Baseline clinical and procedural characteristics were similar between the two groups. At 6 months, the rate of binary restenosis was 17.0% in the PES group compared with 3.6% in the SES group (p = 0.026). Percent restenosis was 24.9 ± 28.6% in the PES group compared with 11.2 ± 17.6% in the SES group (p = 0.004). Length of restenosis segment was 3.21 ± 9.02 mm in the PES group compared with 0.89 ± 2.38 mm in the SES group (p = 0.048). Late loss was 0.73 ± 0.89 mm in the PES group compared with 0.28 ± 0.37 mm in the SES group (p = 0.001). However, there were no differences in clinical outcomes at 1 year including mortality, myocardial infarction, repeat PCI, and major cardiac adverse events between two groups. Conclusion: SES implantation in patients with AMI was associated with reduction in angiographic restenosis at 6 months compared with PES, however, these angiographic benefits were not translated into better clinical outcomes in real world clinical practice.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalJournal of Cardiology
Volume54
Issue number1
DOIs
Publication statusPublished - 2009 Aug 1

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Keywords

  • Acute myocardial infarction
  • Drug-eluting stents
  • Paclitaxel-eluting stents
  • Sirolimus-eluting stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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