Mineralized hyaluronic acid nanoparticles as a robust drug carrier

Song Yi Han, Hwa Seung Han, Sang Cheon Lee, Young Mo Kang, In-San Kim, Jae Hyung Park

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Hyaluronic acid nanoparticles (HA-NPs), mineralized by calcium phosphate, were synthesized as a robust carrier of the anticancer drug, doxorubicin (DOX). The HA-NPs were readily mineralized in the presence of calcium nitrate and ammonium phosphate, which was confirmed by various instruments such as FT-IR, thermogravimetric analysis, transmission electron microscopy, and energy-dispersive X-ray photoelectron spectroscopy. Mineralization reduced the particle size of the HA-NPs in PBS (pH 7.4) from 263 nm to 142 nm, indicating the formation of compact nanoparticles. Mineralized HA-NPs were highly stable at pH 7.4, whereas their particle size rapidly increased in a mildly acidic solution, which was due to the dissolution of calcium phosphate. When DOX-loaded bare HA-NPs were exposed to buffer solutions of various pH, most of the DOX (>80%) was released within 48 h, and the release behavior was not dependent upon the pH of the solution. Notably, the mineralized HA-NPs released DOX in a sustained manner at pH 7.4, whereas a rapid release of DOX was observed in the acidic solution. The release rate of DOX from the mineralized HA-NPs was higher in the solution with a lower pH. These results indicate that mineralized HA-NPs have potential as robust nanoparticles that can release DOX at specific sites under mildly acidic conditions, such as in the extracellular matrix of tumor tissue and in intracellular compartments (e.g., endosome and lysosome) of the cell.

Original languageEnglish
Pages (from-to)7996-8001
Number of pages6
JournalJournal of Materials Chemistry
Volume21
Issue number22
DOIs
Publication statusPublished - 2011 Jun 14
Externally publishedYes

Fingerprint

Hyaluronic acid
Drug Carriers
Hyaluronic Acid
Nanoparticles
Doxorubicin
Calcium phosphate
Particle size
Thermogravimetric analysis
Tumors
Calcium
Nitrates
Buffers
Dissolution
Phosphates
X ray photoelectron spectroscopy
Tissue
Transmission electron microscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Cite this

Han, S. Y., Han, H. S., Lee, S. C., Kang, Y. M., Kim, I-S., & Park, J. H. (2011). Mineralized hyaluronic acid nanoparticles as a robust drug carrier. Journal of Materials Chemistry, 21(22), 7996-8001. https://doi.org/10.1039/c1jm10466g

Mineralized hyaluronic acid nanoparticles as a robust drug carrier. / Han, Song Yi; Han, Hwa Seung; Lee, Sang Cheon; Kang, Young Mo; Kim, In-San; Park, Jae Hyung.

In: Journal of Materials Chemistry, Vol. 21, No. 22, 14.06.2011, p. 7996-8001.

Research output: Contribution to journalArticle

Han, Song Yi ; Han, Hwa Seung ; Lee, Sang Cheon ; Kang, Young Mo ; Kim, In-San ; Park, Jae Hyung. / Mineralized hyaluronic acid nanoparticles as a robust drug carrier. In: Journal of Materials Chemistry. 2011 ; Vol. 21, No. 22. pp. 7996-8001.
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