Minor components of aminoglycosides: Recent advances in their biosynthesis and therapeutic potential

Yeon Hee Ban, Myoung Chong Song, Je Won Park, Yeo Joon Yoon

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Covering: up to 2019 There is significant demand for new aminoglycoside antibiotics due to the widespread emergence of multidrug-resistant Gram-negative bacteria and their high toxicity, but these are not easily accessible in nature because their biosynthetic gene clusters are less commonly found in actinomycetes than are other natural products. Mining minor aminoglycoside components whose pharmacological activity has not yet been assessed could be an alternative approach for the development of next-generation antibiotics for use in the post-antibiotic era. Here, we review the biosynthetic steps responsible for the structural diversity of aminoglycosides and highlight current developments regarding the use of natural minor and semi-synthetic aminoglycosides as promising therapeutic leads or candidates.

Original languageEnglish
Pages (from-to)301-311
Number of pages11
JournalNatural Product Reports
Volume37
Issue number3
DOIs
Publication statusPublished - 2020 Mar

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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