TY - JOUR
T1 - MiR-146a levels in rheumatoid arthritis and their correlation with disease activity
T2 - a meta-analysis
AU - Bae, Sang Cheol
AU - Lee, Young H.
N1 - Funding Information:
This study was supported in part by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958).
Publisher Copyright:
© 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
PY - 2018/7
Y1 - 2018/7
N2 - Objective: To evaluate the relationship between miR-146a levels and rheumatoid arthritis (RA), and the correlation with RA activity. Methods: For the meta-analysis, we searched the PubMed, MEDLINE, EMBASE and Cochrane databases, comparing miR-146a levels in patients with RA and controls, and correlation coefficients between miR-146a levels and Disease Activity Score for 28 joints (DAS28) and erythrocyte sedimentation rate (ESR) in patients with RA. Results: Fourteen studies, totaling 683 patients with RA and 477 controls, were available. miR-146a levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.546, 95% CI = 0.033–1.059, P = 0.037). Stratification by adjustment for age and/or sex revealed significantly higher miR-146a levels in the adjusted, but not in the non-adjusted group (SMD = 0.747, 95% CI = 0.094–1.400, P = 0.025; SMD = 0.431, 95% CI = −0.430–1.291, P = 0.326, respectively). Stratification by sample size showed significantly higher miR-146a levels in RA groups of large sample sizes (N ≥ 50), but not in those of small size. miR-146a levels in synovial tissue/fluid were significantly higher in the RA group than in the OA group (SMD = 1.305, 95% CI = 1010–1.639, P < 0.001). A significant positive correlation was found between miR-146a levels and ESR (correlation coefficient = 0.534, 95% CI = 0.029–0.822, P = 0.039). Conclusions: Circulating and synovial tissue/fluid miR-146a levels are high in patients with RA, and circulating miR-146a levels positively correlate with ESR.
AB - Objective: To evaluate the relationship between miR-146a levels and rheumatoid arthritis (RA), and the correlation with RA activity. Methods: For the meta-analysis, we searched the PubMed, MEDLINE, EMBASE and Cochrane databases, comparing miR-146a levels in patients with RA and controls, and correlation coefficients between miR-146a levels and Disease Activity Score for 28 joints (DAS28) and erythrocyte sedimentation rate (ESR) in patients with RA. Results: Fourteen studies, totaling 683 patients with RA and 477 controls, were available. miR-146a levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.546, 95% CI = 0.033–1.059, P = 0.037). Stratification by adjustment for age and/or sex revealed significantly higher miR-146a levels in the adjusted, but not in the non-adjusted group (SMD = 0.747, 95% CI = 0.094–1.400, P = 0.025; SMD = 0.431, 95% CI = −0.430–1.291, P = 0.326, respectively). Stratification by sample size showed significantly higher miR-146a levels in RA groups of large sample sizes (N ≥ 50), but not in those of small size. miR-146a levels in synovial tissue/fluid were significantly higher in the RA group than in the OA group (SMD = 1.305, 95% CI = 1010–1.639, P < 0.001). A significant positive correlation was found between miR-146a levels and ESR (correlation coefficient = 0.534, 95% CI = 0.029–0.822, P = 0.039). Conclusions: Circulating and synovial tissue/fluid miR-146a levels are high in patients with RA, and circulating miR-146a levels positively correlate with ESR.
KW - MiR-146a
KW - activity
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85049317564&partnerID=8YFLogxK
U2 - 10.1111/1756-185X.13338
DO - 10.1111/1756-185X.13338
M3 - Review article
C2 - 29968332
AN - SCOPUS:85049317564
VL - 21
SP - 1335
EP - 1342
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 7
ER -