TY - JOUR
T1 - Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis
AU - Jiang, Shaoning
AU - Park, Dae Won
AU - Stigler, William S.
AU - Creighton, Judy
AU - Ravi, Saranya
AU - Darley-Usmar, Victor
AU - Zmijewski, Jaroslaw W.
PY - 2013/9/6
Y1 - 2013/9/6
N2 - Background: Billions of cells undergo apoptosis in the human body every day, and the removal of dying cells (efferocytosis) is essential for tissue homeostasis. Results: Energy demand during efferocytosis results in AMPK activation followed by enhancement of macrophage chemokinesis and efferocytosis. Conclusion: The AMPK pathway is intimately linked to cellular bioenergetics and efferocytosis. Significance: A novel mechanism of mitochondria and AMPK-dependent stimulation of efferocytosis is proposed.
AB - Background: Billions of cells undergo apoptosis in the human body every day, and the removal of dying cells (efferocytosis) is essential for tissue homeostasis. Results: Energy demand during efferocytosis results in AMPK activation followed by enhancement of macrophage chemokinesis and efferocytosis. Conclusion: The AMPK pathway is intimately linked to cellular bioenergetics and efferocytosis. Significance: A novel mechanism of mitochondria and AMPK-dependent stimulation of efferocytosis is proposed.
UR - http://www.scopus.com/inward/record.url?scp=84883738441&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.489468
DO - 10.1074/jbc.M113.489468
M3 - Article
C2 - 23897815
AN - SCOPUS:84883738441
VL - 288
SP - 26013
EP - 26026
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 36
ER -