Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis

Shaoning Jiang; Dae Won Park; William S. Stigler; Judy Creighton; Saranya Ravi; Victor Darley-Usmar; Jaroslaw W. Zmijewski

doi:10.1074/jbc.M113.489468

Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis

Shaoning Jiang, Dae Won Park, William S. Stigler, Judy Creighton, Saranya Ravi, Victor Darley-Usmar, Jaroslaw W. Zmijewski

Department of Infectious Diseases

Research output: Contribution to journal › Article

30 Citations (Scopus)

Abstract

Background: Billions of cells undergo apoptosis in the human body every day, and the removal of dying cells (efferocytosis) is essential for tissue homeostasis. Results: Energy demand during efferocytosis results in AMPK activation followed by enhancement of macrophage chemokinesis and efferocytosis. Conclusion: The AMPK pathway is intimately linked to cellular bioenergetics and efferocytosis. Significance: A novel mechanism of mitochondria and AMPK-dependent stimulation of efferocytosis is proposed.

Original language	English
Pages (from-to)	26013-26026
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.489468
Publication status	Published - 2013 Sep 6

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ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

Cite this

Jiang, S., Park, D. W., Stigler, W. S., Creighton, J., Ravi, S., Darley-Usmar, V., & Zmijewski, J. W. (2013). Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis. Journal of Biological Chemistry, 288(36), 26013-26026. https://doi.org/10.1074/jbc.M113.489468

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10.1074/jbc.M113.489468