Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis

Shaoning Jiang, Dae Won Park, William S. Stigler, Judy Creighton, Saranya Ravi, Victor Darley-Usmar, Jaroslaw W. Zmijewski

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Background: Billions of cells undergo apoptosis in the human body every day, and the removal of dying cells (efferocytosis) is essential for tissue homeostasis. Results: Energy demand during efferocytosis results in AMPK activation followed by enhancement of macrophage chemokinesis and efferocytosis. Conclusion: The AMPK pathway is intimately linked to cellular bioenergetics and efferocytosis. Significance: A novel mechanism of mitochondria and AMPK-dependent stimulation of efferocytosis is proposed.

    Original languageEnglish
    Pages (from-to)26013-26026
    Number of pages14
    JournalJournal of Biological Chemistry
    Volume288
    Issue number36
    DOIs
    Publication statusPublished - 2013 Sep 6

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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