@article{06c12e878e77423c968e1a3d1f0db10b,
title = "Mitochondria-targeted nanotheranostic: Harnessing single-laser-activated dual phototherapeutic processing for hypoxic tumor treatment",
abstract = "Realizing maximum tumor suppression along with preventing tumor regrowth by optimizing the photon usage in phototherapy remains a major challenge. Herein, a mitochondria-targeted phototheranostic nanoformulation (MsPDTT NPs) was prepared from a molecular theranostic encapsulated into phospholipids. Notably, under single 690 nm laser excitation, MsPDTT NPs can perform dual-mode photoacoustic and near-infrared fluorescence imaging and potent photodynamic therapy/photothermal therapy (PDT/PTT) because of efficient excited-state deactivation pathways (through radiative and energy transfer to generate reactive oxygen species and non-radiative relaxation). The reference RsPDTT NPs lacking the mitochondria-targeting feature exhibit only the PTT property. Based on biological results, the MsPDTT NP therapeutic response can be switched to PDT and PTT under normoxic and hypoxic environments and maximize the overall efficacy of phototherapies without any noticeable side effects. The current findings suggest the potential of using simultaneous PDT/PTT with proper photon utilization as a promising theranostic approach for hypoxic tumor photoablation.",
keywords = "dual phototherapeutic agent, MAP6: Development, mitochondria-targeted nanotherapeutic, nanoformulation, nanotheranostics, photodynamic therapy, photothermal therapy, tumor hypoxia",
author = "Jinwoo Shin and Yuling Xu and Seyoung Koo and Lim, {Jong Hyeon} and Lee, {Jin Yong} and Amit Sharma and Yao Sun and Kim, {Jong Seung}",
note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) and funded by the Ministry of Science and Innovation, New Zealand (CRI project 2018R1A3B1052702, J.S.K.) and Basic Science Research Program ( 2020R1A6A3A01100558 , S.K.). This work is also supported by the NSFC ( 22022404 and 22074050 ), NSFHP ( 2017CFB151 ), and self-determined research funds of the CCNU from the colleges, basic research, and operation of MOE , Wuhan, scientific and technological projects ( 2019020701011441 ). A.S. thanks the Department of Biotechnology, New Delhi, for the prestigious Ramalingaswami Fellowship 2019 (grant BT/RLF/Re-entry/59/2018 ). The Korea Basic Science Institute (Seoul) is acknowledged for the MALDI-TOF MS data, and Dr. Jung at the KBSI (Seoul) is thanked for taking the MALDI-TOF MS data. Funding Information: This work was supported by the National Research Foundation of Korea (NRF) and funded by the Ministry of Science and Innovation, New Zealand (CRI project 2018R1A3B1052702, J.S.K.) and Basic Science Research Program (2020R1A6A3A01100558, S.K.). This work is also supported by the NSFC (22022404 and 22074050), NSFHP (2017CFB151), and self-determined research funds of the CCNU from the colleges, basic research, and operation of MOE, Wuhan, scientific and technological projects (2019020701011441). A.S. thanks the Department of Biotechnology, New Delhi, for the prestigious Ramalingaswami Fellowship 2019 (grant BT/RLF/Re-entry/59/2018). The Korea Basic Science Institute (Seoul) is acknowledged for the MALDI-TOF MS data, and Dr. Jung at the KBSI (Seoul) is thanked for taking the MALDI-TOF MS data. J.S. S.K. and A.S. contributed to synthesis, characterization, and solution experiments; Y.X. contributed biological experiments; Y.X. performed statistical analyses; J.H.L. contributed to theoretical analysis; J.S. Y.X. S.K. J.H.L. J.Y.L. A.S. Y.S. and J.S.K. contributed to writing, review, and editing; S.K. A.S. Y.S. and J.S.K. received study-enabling funding; A.S. contributed to the initial project conception; and J.Y.L. A.S. Y.S. and J.S.K. contributed to supervision and project development. All authors proofread, commented on, and approved the final version of the manuscript. There are no competing interests to declare. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jul,
day = "7",
doi = "10.1016/j.matt.2021.05.022",
language = "English",
volume = "4",
pages = "2508--2521",
journal = "Matter",
issn = "2590-2393",
publisher = "Cell Press",
number = "7",
}