Mitochondrial dysfunction and immune cell metabolism in sepsis

Dae Won Park; Jaroslaw W. Zmijewski

doi:10.3947/ic.2017.49.1.10

Mitochondrial dysfunction and immune cell metabolism in sepsis

Dae Won Park, Jaroslaw W. Zmijewski

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

Original language	English
Pages (from-to)	10-21
Number of pages	12
Journal	Infection and Chemotherapy
Volume	49
Issue number	1
DOIs	https://doi.org/10.3947/ic.2017.49.1.10
Publication status	Published - 2017 Mar 1
Externally published	Yes

Keywords

Immune cell
Metabolism
Mitochondria
Multi-organ failure
Sepsis

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3947/ic.2017.49.1.10

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abstract = "Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.",

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AU - Park, Dae Won

AU - Zmijewski, Jaroslaw W.

N1 - Funding Information: Park, D.W. was supported by grants from Korea University (K1032201, K1613721) and JW Zmijewski was supported by National Institutes of Health Grant (HL107585). Publisher Copyright: © 2017 by The Korean Society of Infectious Diseases.

PY - 2017/3/1

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N2 - Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

AB - Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

KW - Immune cell

KW - Metabolism

KW - Mitochondria

KW - Multi-organ failure

KW - Sepsis

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DO - 10.3947/ic.2017.49.1.10

M3 - Review article

AN - SCOPUS:85016753858

SN - 2093-2340

VL - 49

SP - 10

EP - 21

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

IS - 1

ER -

Mitochondrial dysfunction and immune cell metabolism in sepsis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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