Mitochondrial dysfunction and immune cell metabolism in sepsis

Dae Won Park, Jaroslaw W. Zmijewski

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalInfection and Chemotherapy
Volume49
Issue number1
DOIs
Publication statusPublished - 2017 Mar 1

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Keywords

  • Immune cell
  • Metabolism
  • Mitochondria
  • Multi-organ failure
  • Sepsis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

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