Mitochondrial dysfunction and immune cell metabolism in sepsis

Dae Won Park, Jaroslaw W. Zmijewski

    Research output: Contribution to journalReview articlepeer-review

    21 Citations (Scopus)

    Abstract

    Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

    Original languageEnglish
    Pages (from-to)10-21
    Number of pages12
    JournalInfection and Chemotherapy
    Volume49
    Issue number1
    DOIs
    Publication statusPublished - 2017 Mar 1

    Keywords

    • Immune cell
    • Metabolism
    • Mitochondria
    • Multi-organ failure
    • Sepsis

    ASJC Scopus subject areas

    • Infectious Diseases
    • Pharmacology (medical)

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