Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

Mi Jin Kim, Young A. Yoo, Hyung Jung Kim, Seong Man Kang, Yong Geon Kim, Jun Suk Kim, Young Do Yoo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume338
Issue number2
DOIs
Publication statusPublished - 2005 Dec 16

Fingerprint

Ribosomal Proteins
Mitochondrial Proteins
Starvation
Cell Cycle Checkpoints
Cells
Apoptosis
Cell proliferation
Serum
Small Interfering RNA
Cell Proliferation
Growth

Keywords

  • Cell cycle
  • MRPL41
  • p21
  • p27
  • p53
  • Serum starvation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1 . / Kim, Mi Jin; Yoo, Young A.; Kim, Hyung Jung; Kang, Seong Man; Kim, Yong Geon; Kim, Jun Suk; Yoo, Young Do.

In: Biochemical and Biophysical Research Communications, Vol. 338, No. 2, 16.12.2005, p. 1179-1184.

Research output: Contribution to journalArticle

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