Abstract
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1179-1184 |
| Number of pages | 6 |
| Journal | Biochemical and biophysical research communications |
| Volume | 338 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Dec 16 |
Keywords
- Cell cycle
- MRPL41
- Serum starvation
- p21
- p27
- p53
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Kim, M. J., Yoo, Y. A., Kim, H. J., Kang, S., Kim, Y. G., Kim, J. S., & Yoo, Y. D. (2005). Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1. Biochemical and biophysical research communications, 338(2), 1179-1184. https://doi.org/10.1016/j.bbrc.2005.10.064