Abstract
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1179-1184 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 338 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Dec 16 |
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Keywords
- Cell cycle
- MRPL41
- p21
- p27
- p53
- Serum starvation
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1 . / Kim, Mi Jin; Yoo, Young A.; Kim, Hyung Jung; Kang, Seong Man; Kim, Yong Geon; Kim, Jun Suk; Yoo, Young Do.
In: Biochemical and Biophysical Research Communications, Vol. 338, No. 2, 16.12.2005, p. 1179-1184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1
AU - Kim, Mi Jin
AU - Yoo, Young A.
AU - Kim, Hyung Jung
AU - Kang, Seong Man
AU - Kim, Yong Geon
AU - Kim, Jun Suk
AU - Yoo, Young Do
PY - 2005/12/16
Y1 - 2005/12/16
N2 - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
AB - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
KW - Cell cycle
KW - MRPL41
KW - p21
KW - p27
KW - p53
KW - Serum starvation
UR - http://www.scopus.com/inward/record.url?scp=27744592260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744592260&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2005.10.064
DO - 10.1016/j.bbrc.2005.10.064
M3 - Article
C2 - 16256947
AN - SCOPUS:27744592260
VL - 338
SP - 1179
EP - 1184
JO - The BMJ
JF - The BMJ
SN - 0730-6512
IS - 2
ER -