Mitochondrial-targeted two-photon fluorescent probes for zinc ions, H 2 o 2, and thiols in living tissues

Hwan Myung Kim, Bong-Rae Cho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to monitor each of these chemical species in the mitochondria at the cell, tissue, and organism levels. An ideal tool for such purpose is the use of two-photon microscopy (TPM). Until recently, however, there has been no report on the two-photon (TP) probes suitable for such applications. In this paper, we summarize the mitochondria-targeted TP probes for Zn2+, H and thiols, as well as their bioimaging applications.

Original languageEnglish
Article number323619
JournalOxidative Medicine and Cellular Longevity
DOIs
Publication statusPublished - 2013 Mar 11

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Mitochondria
Fluorescent Dyes
Photons
Sulfhydryl Compounds
Zinc
Ions
Tissue
Oxygen Consumption
Oxidation-Reduction
Metal ions
Glutathione
Microscopy
Reactive Oxygen Species
Microscopic examination
Metals
Oxygen

ASJC Scopus subject areas

  • Cell Biology
  • Ageing
  • Biochemistry

Cite this

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