MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

Chang Sub Uhm, Young Suk Suh, Joo Bae Park, Moon Bang Sohn, Im Joo Rhyu, Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalNeuroscience Letters
Volume255
Issue number2
DOIs
Publication statusPublished - 1998 Sep 2

Fingerprint

Inositol 1,4,5-Trisphosphate Receptors
Dizocilpine Maleate
Gerbillinae
N-Methylaspartate
Ischemia
Messenger RNA
Brain
Parahippocampal Gyrus
Common Carotid Artery
Dentate Gyrus
Brain Ischemia
In Situ Hybridization
aspartic acid receptor

Keywords

  • In situ hybridization
  • IP receptor
  • Ischemia
  • MK-801
  • Mongolian gerbil
  • N- Methyl-D-aspartic acid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain. / Uhm, Chang Sub; Suh, Young Suk; Park, Joo Bae; Sohn, Moon Bang; Rhyu, Im Joo; Kim, Hyun.

In: Neuroscience Letters, Vol. 255, No. 2, 02.09.1998, p. 111-114.

Research output: Contribution to journalArticle

@article{17dd20bf35f44afbb2587b3896173d1c,
title = "MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain",
abstract = "Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.",
keywords = "In situ hybridization, IP receptor, Ischemia, MK-801, Mongolian gerbil, N- Methyl-D-aspartic acid receptor",
author = "Uhm, {Chang Sub} and Suh, {Young Suk} and Park, {Joo Bae} and Sohn, {Moon Bang} and Rhyu, {Im Joo} and Hyun Kim",
year = "1998",
month = "9",
day = "2",
doi = "10.1016/S0304-3940(98)00727-7",
language = "English",
volume = "255",
pages = "111--114",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - MK-801, a non-competitive NMDA receptor antagonist, prevents postischemic decrease of inositol 1,4,5-trisphosphate receptor mRNA expression in mongolian gerbil brain

AU - Uhm, Chang Sub

AU - Suh, Young Suk

AU - Park, Joo Bae

AU - Sohn, Moon Bang

AU - Rhyu, Im Joo

AU - Kim, Hyun

PY - 1998/9/2

Y1 - 1998/9/2

N2 - Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.

AB - Changes of inositol 1,4,5-trisphosphate receptor (IP3R) mRNA expression after transient brain ischemia and the effect of MK-801, a non-competitive N- methyl-D-aspartic acid (NMDA) receptor antagonist, on the IP3R mRNA expression was studied in mongolian gerbil brain by in situ hybridization. Transient ischemia was induced by ligating left common carotid artery for 10 min, and the animals were allowed recovery from 15 min to 24 h. MK-801 was introduced intraperitoneally 30 min before ischemia. IP3R mRNA expression was decreased in dentate gyrus and hippocampus from 90 min until 24 h after ischemia. MK-801 pretreatment prevented the change of IP3R mRNA expression after ischemia. These results suggest that IP3R mRNA expression in ischemia may be related with NMDA receptor.

KW - In situ hybridization

KW - IP receptor

KW - Ischemia

KW - MK-801

KW - Mongolian gerbil

KW - N- Methyl-D-aspartic acid receptor

UR - http://www.scopus.com/inward/record.url?scp=0032475462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032475462&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(98)00727-7

DO - 10.1016/S0304-3940(98)00727-7

M3 - Article

VL - 255

SP - 111

EP - 114

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -