Modeling sparse connectivity between underlying brain sources for EEG/MEG

Stefan Haufe, Ryota Tomioka, Guido Nolte, Klaus Robert Müller, Motoaki Kawanabe

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76 Citations (Scopus)

Abstract

We propose a novel technique to assess functional brain connectivity in electroencephalographic (EEG)/magnetoencephalographic (MEG) signals. Our method, called sparsely connected sources analysis (SCSA), can overcome the problem of volume conduction by modeling neural data innovatively with the following ingredients: 1) the EEG/MEG is assumed to be a linear mixture of correlated sources following a multivariate autoregressive (MVAR) model; 2) the demixing is estimated jointly with the source MVAR parameters; and 3) overfitting is avoided by using the group lasso penalty. This approach allows us to extract the appropriate level of crosstalk between the extracted sources and, in this manner, we obtain a sparse data-driven model of functional connectivity. We demonstrate the usefulness of SCSA with simulated data and compare it to a number of existing algorithms with excellent results.

Original languageEnglish
Article number5466024
Pages (from-to)1954-1963
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume57
Issue number8
DOIs
Publication statusPublished - 2010 Aug
Externally publishedYes

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Keywords

  • Convolutive independent component analysis (ICA)
  • Granger Causality
  • electroencephalographic (EEG)
  • functional connectivity
  • magnetoencephalography (MEG)
  • source multivariate AR (MVAR) model

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Haufe, S., Tomioka, R., Nolte, G., Müller, K. R., & Kawanabe, M. (2010). Modeling sparse connectivity between underlying brain sources for EEG/MEG. IEEE Transactions on Biomedical Engineering, 57(8), 1954-1963. [5466024]. https://doi.org/10.1109/TBME.2010.2046325