Moderate alcohol intake reduces risk of ischemic stroke in Korea

Soo Joo Lee, Yong Jin Cho, Jae Guk Kim, Youngchai Ko, Keun Sik Hong, Jong Moo Park, Kyusik Kang, Tai Hwan Park, Sang Soon Park, Kyung Bok Lee, Jae Kwan Cha, Dae Hyun Kim, Jun Lee, Joon Tae Kim, Juneyoung Lee, Ji Sung Lee, Myung Suk Jang, Moon Ku Han, Philip B. Gorelick, Hee Joon Bae

Research output: Contribution to journalArticle

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Abstract

Objective: We undertook a population-based, case-control study to examine a dose-response relationship between alcohol intake and risk of ischemic stroke in Koreans who had different alcoholic beverage type preferences than Western populations and to examine the effect modifications by sex and ischemic stroke subtypes. Methods: Cases (n 1,848) were recruited from patients aged 20 years or older with first-ever ischemic stroke. Stroke-free controls (n 3,589) were from the fourth and fifth Korean National Health and Nutrition Examination Survey and were matched to the cases by age (±3 years), sex, and education level. All participants completed an interview using a structured questionnaire about alcohol intake. Results: Light to moderate alcohol intake, 3 or 4 drinks (1 drink 10 g ethanol) per day, was significantly associated with a lower odds of ischemic stroke after adjusting for potential confounders (no drinks: reference; <1 drink: odds ratio 0.38, 95% confidence interval 0.32-0.45; 1-2 drinks: 0.45, 0.36-0.57; and 3-4 drinks: 0.54, 0.39-0.74). The threshold of alcohol effect in women was slightly lower than that in men (up to 1-2 drinks in women vs up to 3-4 drinks in men), but this difference was not statistically significant. There was no statistical interaction between alcohol intake and the subtypes of ischemic stroke (p 0.50). The most frequently used alcoholic beverage was one native to Korea, soju (78% of the cases), a distilled beverage with 20% ethanol by volume. Conclusions: Our findings suggest that light to moderate distilled alcohol consumption may reduce the risk of ischemic stroke in Koreans.

Original languageEnglish
Pages (from-to)1950-1956
Number of pages7
JournalNeurology
Volume85
Issue number22
DOIs
Publication statusPublished - 2015 Dec 1

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Korea
Stroke
Alcohols
Alcoholic Beverages
Ethanol
Light
Sex Education
Nutrition Surveys
Beverages
Alcohol Drinking
Population
Case-Control Studies
Odds Ratio
Confidence Intervals
Interviews

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lee, S. J., Cho, Y. J., Kim, J. G., Ko, Y., Hong, K. S., Park, J. M., ... Bae, H. J. (2015). Moderate alcohol intake reduces risk of ischemic stroke in Korea. Neurology, 85(22), 1950-1956. https://doi.org/10.1212/WNL.0000000000002165

Moderate alcohol intake reduces risk of ischemic stroke in Korea. / Lee, Soo Joo; Cho, Yong Jin; Kim, Jae Guk; Ko, Youngchai; Hong, Keun Sik; Park, Jong Moo; Kang, Kyusik; Park, Tai Hwan; Park, Sang Soon; Lee, Kyung Bok; Cha, Jae Kwan; Kim, Dae Hyun; Lee, Jun; Kim, Joon Tae; Lee, Juneyoung; Lee, Ji Sung; Jang, Myung Suk; Han, Moon Ku; Gorelick, Philip B.; Bae, Hee Joon.

In: Neurology, Vol. 85, No. 22, 01.12.2015, p. 1950-1956.

Research output: Contribution to journalArticle

Lee, SJ, Cho, YJ, Kim, JG, Ko, Y, Hong, KS, Park, JM, Kang, K, Park, TH, Park, SS, Lee, KB, Cha, JK, Kim, DH, Lee, J, Kim, JT, Lee, J, Lee, JS, Jang, MS, Han, MK, Gorelick, PB & Bae, HJ 2015, 'Moderate alcohol intake reduces risk of ischemic stroke in Korea', Neurology, vol. 85, no. 22, pp. 1950-1956. https://doi.org/10.1212/WNL.0000000000002165
Lee SJ, Cho YJ, Kim JG, Ko Y, Hong KS, Park JM et al. Moderate alcohol intake reduces risk of ischemic stroke in Korea. Neurology. 2015 Dec 1;85(22):1950-1956. https://doi.org/10.1212/WNL.0000000000002165
Lee, Soo Joo ; Cho, Yong Jin ; Kim, Jae Guk ; Ko, Youngchai ; Hong, Keun Sik ; Park, Jong Moo ; Kang, Kyusik ; Park, Tai Hwan ; Park, Sang Soon ; Lee, Kyung Bok ; Cha, Jae Kwan ; Kim, Dae Hyun ; Lee, Jun ; Kim, Joon Tae ; Lee, Juneyoung ; Lee, Ji Sung ; Jang, Myung Suk ; Han, Moon Ku ; Gorelick, Philip B. ; Bae, Hee Joon. / Moderate alcohol intake reduces risk of ischemic stroke in Korea. In: Neurology. 2015 ; Vol. 85, No. 22. pp. 1950-1956.
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abstract = "Objective: We undertook a population-based, case-control study to examine a dose-response relationship between alcohol intake and risk of ischemic stroke in Koreans who had different alcoholic beverage type preferences than Western populations and to examine the effect modifications by sex and ischemic stroke subtypes. Methods: Cases (n 1,848) were recruited from patients aged 20 years or older with first-ever ischemic stroke. Stroke-free controls (n 3,589) were from the fourth and fifth Korean National Health and Nutrition Examination Survey and were matched to the cases by age (±3 years), sex, and education level. All participants completed an interview using a structured questionnaire about alcohol intake. Results: Light to moderate alcohol intake, 3 or 4 drinks (1 drink 10 g ethanol) per day, was significantly associated with a lower odds of ischemic stroke after adjusting for potential confounders (no drinks: reference; <1 drink: odds ratio 0.38, 95{\%} confidence interval 0.32-0.45; 1-2 drinks: 0.45, 0.36-0.57; and 3-4 drinks: 0.54, 0.39-0.74). The threshold of alcohol effect in women was slightly lower than that in men (up to 1-2 drinks in women vs up to 3-4 drinks in men), but this difference was not statistically significant. There was no statistical interaction between alcohol intake and the subtypes of ischemic stroke (p 0.50). The most frequently used alcoholic beverage was one native to Korea, soju (78{\%} of the cases), a distilled beverage with 20{\%} ethanol by volume. Conclusions: Our findings suggest that light to moderate distilled alcohol consumption may reduce the risk of ischemic stroke in Koreans.",
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AU - Cho, Yong Jin

AU - Kim, Jae Guk

AU - Ko, Youngchai

AU - Hong, Keun Sik

AU - Park, Jong Moo

AU - Kang, Kyusik

AU - Park, Tai Hwan

AU - Park, Sang Soon

AU - Lee, Kyung Bok

AU - Cha, Jae Kwan

AU - Kim, Dae Hyun

AU - Lee, Jun

AU - Kim, Joon Tae

AU - Lee, Juneyoung

AU - Lee, Ji Sung

AU - Jang, Myung Suk

AU - Han, Moon Ku

AU - Gorelick, Philip B.

AU - Bae, Hee Joon

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N2 - Objective: We undertook a population-based, case-control study to examine a dose-response relationship between alcohol intake and risk of ischemic stroke in Koreans who had different alcoholic beverage type preferences than Western populations and to examine the effect modifications by sex and ischemic stroke subtypes. Methods: Cases (n 1,848) were recruited from patients aged 20 years or older with first-ever ischemic stroke. Stroke-free controls (n 3,589) were from the fourth and fifth Korean National Health and Nutrition Examination Survey and were matched to the cases by age (±3 years), sex, and education level. All participants completed an interview using a structured questionnaire about alcohol intake. Results: Light to moderate alcohol intake, 3 or 4 drinks (1 drink 10 g ethanol) per day, was significantly associated with a lower odds of ischemic stroke after adjusting for potential confounders (no drinks: reference; <1 drink: odds ratio 0.38, 95% confidence interval 0.32-0.45; 1-2 drinks: 0.45, 0.36-0.57; and 3-4 drinks: 0.54, 0.39-0.74). The threshold of alcohol effect in women was slightly lower than that in men (up to 1-2 drinks in women vs up to 3-4 drinks in men), but this difference was not statistically significant. There was no statistical interaction between alcohol intake and the subtypes of ischemic stroke (p 0.50). The most frequently used alcoholic beverage was one native to Korea, soju (78% of the cases), a distilled beverage with 20% ethanol by volume. Conclusions: Our findings suggest that light to moderate distilled alcohol consumption may reduce the risk of ischemic stroke in Koreans.

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