TY - JOUR
T1 - Modest weight loss does not increase plasma adiponectin levels
T2 - effects of weight loss on C-reactive protein and DNA damage
AU - Shin, Min Jeong
AU - Yoen Kim, Oh
AU - Koh, Soo Jeong
AU - Chae, Jey Sook
AU - Kim, Ji Young
AU - Jang, Yangsoo
AU - Lee, Jong Ho
N1 - Funding Information:
This study was supported by grants from the National Research Laboratory project, Ministry of Science and Technology, Kwachon, Korea (2005-01572), and the Korea Science and Engineering Foundation, Daejeon, Korea (R01-2003-0000-11709-0).
PY - 2006/8
Y1 - 2006/8
N2 - Adiponectin has been reported to have antiatherogenic, antidiabetic properties and was proposed as an important mediator of insulin action and glucose metabolism. This study was conducted to determine weight loss effects on the plasma adiponectin levels and clinical parameters including oxidative DNA damage and C-reactive protein (CRP) in overweight-obese subjects. A total of 184 overweight-obese volunteers underwent a clinical intervention study consisting of -1255 kJ/d for 12 weeks. Anthropometic parameters, blood lipid profiles, glucose, insulin, CRP, and baseline DNA damage using comet assay and adiponectin concentrations were determined at baseline and at 12 weeks of intervention. The treatment induced modest weight loss averaged 4.75% of initial body weight. C-reactive protein (P < .005); baseline DNA damages as measured by tail length (micrometers, P < .05), tail DNA (percentage, P < .001), and tail moment on DNA (P < .001); and the insulin resistance-related variables (P < .01 for glucose; P < .05 for homeostasis model assessment of insulin resistance) showed significant changes toward clinical improvement at the end of the intervention. However, no significant changes in plasma adiponectin levels were found after 12 weeks. When subjects were divided into 3 groups according to the degree of weight change, significant increases in plasma adiponectin levels were found only in the subjects with the greatest weight change. In conclusion, modest weight loss improved metabolic parameters including blood lipids, insulin resistance, CRP, and DNA damage, but did not increase plasma levels of adiponectin in overweight-obese subjects. However, the increases in plasma adiponectin after 12 weeks were observed in the subjects with a higher degree of weight loss.
AB - Adiponectin has been reported to have antiatherogenic, antidiabetic properties and was proposed as an important mediator of insulin action and glucose metabolism. This study was conducted to determine weight loss effects on the plasma adiponectin levels and clinical parameters including oxidative DNA damage and C-reactive protein (CRP) in overweight-obese subjects. A total of 184 overweight-obese volunteers underwent a clinical intervention study consisting of -1255 kJ/d for 12 weeks. Anthropometic parameters, blood lipid profiles, glucose, insulin, CRP, and baseline DNA damage using comet assay and adiponectin concentrations were determined at baseline and at 12 weeks of intervention. The treatment induced modest weight loss averaged 4.75% of initial body weight. C-reactive protein (P < .005); baseline DNA damages as measured by tail length (micrometers, P < .05), tail DNA (percentage, P < .001), and tail moment on DNA (P < .001); and the insulin resistance-related variables (P < .01 for glucose; P < .05 for homeostasis model assessment of insulin resistance) showed significant changes toward clinical improvement at the end of the intervention. However, no significant changes in plasma adiponectin levels were found after 12 weeks. When subjects were divided into 3 groups according to the degree of weight change, significant increases in plasma adiponectin levels were found only in the subjects with the greatest weight change. In conclusion, modest weight loss improved metabolic parameters including blood lipids, insulin resistance, CRP, and DNA damage, but did not increase plasma levels of adiponectin in overweight-obese subjects. However, the increases in plasma adiponectin after 12 weeks were observed in the subjects with a higher degree of weight loss.
KW - Adiponectin
KW - C-reactive protein
KW - DNA damage
KW - Obese subjects
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=33748757227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748757227&partnerID=8YFLogxK
U2 - 10.1016/j.nutres.2006.06.021
DO - 10.1016/j.nutres.2006.06.021
M3 - Article
AN - SCOPUS:33748757227
VL - 26
SP - 391
EP - 396
JO - Nutrition Research
JF - Nutrition Research
SN - 0271-5317
IS - 8
ER -