Modification of mesenchymal stem cells for cardiac regeneration

Heesang Song, Byeong Wook Song, Min Ji Cha, In Geol Choi, Ki Chul Hwang

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

Importance of the field: Mesenchymal stem cells (MSCs) have the greatest potential for use in cell-based therapy of human heart diseases, especially in myocardial infarcts. The therapeutic potential of MSCs in myocardial repair is based on the ability of MSCs to directly differentiate into cardiac tissue and on the paracrine actions of factors released from MSCs. However, the major obstacle in the clinical application of MSC-based therapy is the poor viability of the transplanted cells due to harsh microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, various approaches have been implemented in an effort to improve the survival of implanted MSCs through ex vivo manipulation of MSCs. Areas covered in this review: Major obstacles in MSC-based therapy are discussed, along with recent advances for enhancing therapeutic potential of engrafted MSCs from the past decade. What the reader will gain: This review focuses primarily on ex vivo manipulation of MSCs before transplantation, which includes pretreatment, preconditioning and genetic modification of MSCs, and future directions. Take home message: Modification of MSCs before transplantation has developed into a promising option for enhancing the beneficial effects of MSC-based therapy for cardiac repair after myocardial infarction.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume10
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

    Fingerprint

Keywords

  • Cardiac regenration
  • Cell adhesion
  • Cell survival
  • Mesenchymal stem cell

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this