Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide- co-glycolide) Implants

Eugene Lih, Chang Hun Kum, Wooram Park, So Young Chun, Youngjin Cho, Yoon Ki Joung, Kwang Sook Park, Young Joon Hong, Dong June Ahn, Byung Soo Kim, Tae Gyun Kwon, Myung Ho Jeong, Jeffrey A. Hubbell, Dong Keun Han

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Biodegradable polymers have been extensively used in biomedical applications, ranging from regenerative medicine to medical devices. However, the acidic byproducts resulting from degradation can generate vigorous inflammatory reactions, often leading to clinical failure. We present an approach to prevent acid-induced inflammatory responses associated with biodegradable polymers, here poly(lactide-co-glycolide), by using oligo(lactide)-grafted magnesium hydroxide (Mg(OH)2) nanoparticles, which neutralize the acidic environment. In particular, we demonstrated that incorporating the modified Mg(OH)2 nanoparticles within degradable coatings on drug-eluting arterial stents efficiently attenuates the inflammatory response and in-stent intimal thickening by more than 97 and 60%, respectively, in the porcine coronary artery, compared with that of drug-eluting stent control. We also observed that decreased inflammation allows better reconstruction of mouse renal glomeruli in a kidney tissue regeneration model. Such modified Mg(OH)2 nanoparticles may be useful to extend the applicability and improve clinical success of biodegradable devices used in various biomedical fields.

Original languageEnglish
Pages (from-to)6917-6925
Number of pages9
JournalACS Nano
Volume12
Issue number7
DOIs
Publication statusPublished - 2018 Jul 24

Fingerprint

Magnesium Hydroxide
Polyglactin 910
Stents
hydroxides
Magnesium
magnesium
Biodegradable polymers
Nanoparticles
nanoparticles
drugs
glomerulus
Tissue regeneration
polymers
kidneys
arteries
regeneration
medicine
Pharmaceutical Preparations
mice
Byproducts

Keywords

  • biodegradable polymers
  • biomedical applications
  • inflammation
  • magnesium hydroxide
  • neutralization

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide- co-glycolide) Implants. / Lih, Eugene; Kum, Chang Hun; Park, Wooram; Chun, So Young; Cho, Youngjin; Joung, Yoon Ki; Park, Kwang Sook; Hong, Young Joon; Ahn, Dong June; Kim, Byung Soo; Kwon, Tae Gyun; Jeong, Myung Ho; Hubbell, Jeffrey A.; Han, Dong Keun.

In: ACS Nano, Vol. 12, No. 7, 24.07.2018, p. 6917-6925.

Research output: Contribution to journalArticle

Lih, E, Kum, CH, Park, W, Chun, SY, Cho, Y, Joung, YK, Park, KS, Hong, YJ, Ahn, DJ, Kim, BS, Kwon, TG, Jeong, MH, Hubbell, JA & Han, DK 2018, 'Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide- co-glycolide) Implants', ACS Nano, vol. 12, no. 7, pp. 6917-6925. https://doi.org/10.1021/acsnano.8b02365
Lih, Eugene ; Kum, Chang Hun ; Park, Wooram ; Chun, So Young ; Cho, Youngjin ; Joung, Yoon Ki ; Park, Kwang Sook ; Hong, Young Joon ; Ahn, Dong June ; Kim, Byung Soo ; Kwon, Tae Gyun ; Jeong, Myung Ho ; Hubbell, Jeffrey A. ; Han, Dong Keun. / Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide- co-glycolide) Implants. In: ACS Nano. 2018 ; Vol. 12, No. 7. pp. 6917-6925.
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